Guinea Pig KCNE2 Recombinant Protein – Cat# MBS717652

Potassium Voltage-Gated Channel Subfamily E Member 2 (KCNE2) Guinea Pig Recombinant Protein

Name: KCNE2 Recombinant Protein; Guinea Pig; MyBioSource
Brand: MyBioSource
SKU: MBS717652
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717652

MBS717652 is a recombinant protein targeting Kcne2. Also known as Recombinant Guinea pig Potassium voltage-gated channel subfamily E member 2 (Kcne2). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Potassium voltage-gated channel subfamily E member 2 (Kcne2), Recombinant Protein

Full Product Name

Recombinant Guinea pig Potassium voltage-gated channel subfamily E member 2 (Kcne2)

Product Gene Name

Kcne2 recombinant protein

Product Synonym Names

Potassium voltage-gated channel subfamily E member 2; MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1

Sequence

S TVKSKRREHS QDPYHQYIVE DWQQKYRSQI LHLEDSKATI HENLGATGFT VSP

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

14,356 Da

Sequence Positions

70-123

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P63160

Species

Cavia porcellus (Guinea pig)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Kcne2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcne2. It may not necessarily be applicable to this product.

NCBI GI #

290543348

NCBI GeneID

100135465

NCBI Accession #

NP_001166376.1

UniProt Primary Accession #

P63160

UniProt Secondary Accession #

Q9WTW0

UniProt Related Accession #

P63160

GenBank Nucleotide #

NM_001172905.1

NCBI Official Full Name

potassium voltage-gated channel subfamily E member 2

NCBI Official Symbol

Kcne2

UniProt Protein Name

Potassium voltage-gated channel subfamily E member 2

UniProt Synonym Protein Names

MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

Kcne2

UniProt Entry Name

KCNE2_CAVPO

NCBI Protein Information

potassium voltage-gated channel subfamily E member 2; minK-related peptide 1; potassium channel subunit beta MiRP1; minimum potassium ion channel-related peptide 1

UniProt Comments for Kcne2

KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; cell surface; membrane; lysosome; plasma membrane; integral to membrane

Molecular Function: protein binding; voltage-gated potassium channel activity; potassium channel regulator activity; protein homodimerization activity; delayed rectifier potassium channel activity; cation channel activity; inward rectifier potassium channel activity

Biological Process: tongue development; potassium ion import; aging

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Kcne2 recombinant protein

Disease Name	Pubmed Publications
Long QT Syndrome Antibodies	>113 publications with Kcne2 and Long QT Syndrome
Long Qt Syndrome 6 Antibodies	>29 publications with Kcne2 and Long Qt Syndrome 6
Tachycardia, Ventricular Antibodies	>22 publications with Kcne2 and Tachycardia, Ventricular
Atrial Fibrillation Antibodies	>15 publications with Kcne2 and Atrial Fibrillation
Torsades de Pointes Antibodies	>14 publications with Kcne2 and Torsades de Pointes
Ventricular Fibrillation Antibodies	>11 publications with Kcne2 and Ventricular Fibrillation
Seizures Antibodies	>6 publications with Kcne2 and Seizures
Coronary Disease Antibodies	>4 publications with Kcne2 and Coronary Disease
Neurobehavioral Manifestations Antibodies	>4 publications with Kcne2 and Neurobehavioral Manifestations
Hyperplasia Antibodies	>3 publications with Kcne2 and Hyperplasia