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Low-Density Lipoprotein Receptor (LDLR) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS717968

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in… More details

$2155 / 0.5 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Low-density lipoprotein receptor (LDLR), Recombinant Protein
Full Product Name
Recombinant Human Low-density lipoprotein receptor (LDLR), partial
Product Gene Name
LDLR recombinant protein
Sequence
AVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN EKKPSSVR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
82,255 Da
Sequence Positions
22-788
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
143890
3D Structure
ModBase 3D Structure for P01130
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LDLR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LDLR purchase

MBS717968 is a recombinant protein targeting LDLR. Also known as Recombinant Human Low-density lipoprotein receptor (LDLR), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for LDLR. It may not necessarily be applicable to this product.

NCBI GI #
4504975
NCBI GeneID
3949
NCBI Accession #
NP_000518.1
UniProt Primary Accession #
P01130
UniProt Secondary Accession #
Q53ZD9; Q59FQ1; Q9UDH7; B4DII3; B4DJZ8; B4DR00; B4DTQ3; C0JYY8; H0YLU8; H0YNT7
UniProt Related Accession #
P01130
GenBank Nucleotide #
NM_000527.4
NCBI Official Full Name
low-density lipoprotein receptor isoform 1
NCBI Official Synonym Full Names
low density lipoprotein receptor
NCBI Official Symbol
LDLR
NCBI Official Synonym Symbols
FH; FHC; LDLCQ2
UniProt Protein Name
Low-density lipoprotein receptor
Protein Family
Low-density lipoprotein receptor
UniProt Gene Name
LDLR
UniProt Synonym Gene Names
LDL receptor
NCBI Protein Information
low-density lipoprotein receptor

NCBI Summary for LDLR

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
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UniProt Comments for LDLR

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

Research Articles on LDLR

1. The genotype-risk associations were examined between LDLR (rs885765, rs688, rs5925, rs55903358, rs5742911) and obesity-related phenotypes and other comorbidities in Sucre, Venezuela. The association between LDLR rs5742911 ancestral genotype A/A and high risk condition related to HDL-cholesterol was the only one found to be significant:(A/A: 41.50+/-14.81 mg/dL; A/G: 45.00+/-12.07 mg/dL; G/G: 47.17+/-9.43 mg/dL).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LDLR recombinant protein

 Reference Product  PubMed Publications
 APOE recombinant protein  >474 publications with LDLR and APOE
 APOB recombinant protein  >368 publications with LDLR and APOB
 PCSK9 recombinant protein  >248 publications with LDLR and PCSK9
 LDLRAP1 recombinant protein  >25 publications with LDLR and LDLRAP1
 LIPC recombinant protein  >14 publications with LDLR and LIPC
 MYLIP recombinant protein  >10 publications with LDLR and MYLIP
 DAB1 recombinant protein  >3 publications with LDLR and DAB1
 LRPAP1 recombinant protein  >3 publications with LDLR and LRPAP1
 APOH recombinant protein  >1 publications with LDLR and APOH

Pathways associated with LDLR recombinant protein

 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram

Diseases associated with LDLR recombinant protein

 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >952 publications with LDLR and Atherosclerosis
 Cardiovascular Diseases Antibodies  >842 publications with LDLR and Cardiovascular Diseases
 Hypercholesterolemia Antibodies  >743 publications with LDLR and Hypercholesterolemia
 Dyslipidemias Antibodies  >737 publications with LDLR and Dyslipidemias
 Hyperlipidemias Antibodies  >689 publications with LDLR and Hyperlipidemias
 HYPERCHOLESTEROLEMIA, FAMILIAL Antibodies  >491 publications with LDLR and HYPERCHOLESTEROLEMIA, FAMILIAL
 Hyperlipoproteinemia Type II Antibodies  >355 publications with LDLR and Hyperlipoproteinemia Type II
 Inflammation Antibodies  >233 publications with LDLR and Inflammation
 Coronary Artery Disease Antibodies  >227 publications with LDLR and Coronary Artery Disease
 Coronary Disease Antibodies  >226 publications with LDLR and Coronary Disease

Organs/Tissues associated with LDLR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1058 publications with LDLR and Blood
 Liver Antibodies  >588 publications with LDLR and Liver
 Vascular Antibodies  >513 publications with LDLR and Vascular
 Heart Antibodies  >275 publications with LDLR and Heart
 Bone Antibodies  >189 publications with LDLR and Bone
 Muscle Antibodies  >171 publications with LDLR and Muscle
 Bone Marrow Antibodies  >159 publications with LDLR and Bone Marrow
 Brain Antibodies  >125 publications with LDLR and Brain
 Kidney Antibodies  >69 publications with LDLR and Kidney
 Ovary Antibodies  >58 publications with LDLR and Ovary
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