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H (+)/Cl (-) Exchange Transporter 7 (CLCN7) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718113

MBS718113 is a recombinant protein targeting Clcn7. Also known as Recombinant Rat H (+)/Cl (-) exchange transporter 7 (Clcn7) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$3645 / 1 mg (E-Coli) +4 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
H (+)/Cl (-) exchange transporter 7 (Clcn7), Recombinant Protein
Full Product Name
Recombinant Rat H (+)/Cl (-) exchange transporter 7 (Clcn7) , partial
Product Gene Name
Clcn7 recombinant protein
Sequence
MANVSKKVSW SGRDRDDEEG APLLRRTGQP DEETPLLNGA GPGARQSHSA LFRIGQMNNV ELDDELLDPE VDPPHTFPKE IPHNEKLLSL KYESLDYDNS ENQLFLEEER RINHTAFRTV EIKRWVICAL IGILTGLVAC FIDIVVENLA GLKYRVIKDN IDKFTEKGGL SFSLLLWATL NSAFVLVGSV IVAFIEPVAA GSGIPQIKCF LNGVKIPHVV RLKTLVIKVS GVILSVVGGL AVGKEGPMIH SGSVIAAGIS QGRSTSLKRD FKIFEYFRRD TEKRDFVSAG AAAGVSAAFG APVGGVLFSL EEGASFWNQF LTWRIFFASM ISTFTLNFVL SIYHGNMWDL SSPGLINFGR FDSEKMAYTI HEIPVFIAMG VVGGILGAVF NALNYWLTMF RIRYIHRPCL QVIEAMLVAA VTATVAFVLI YSSRDCQPLQ GSSMSYPLQL FCADGEYNSM AAAFFNTPEK SVVSLFHDPP GSYNPMTLGL FTLVYFFLAC WTYGLTVSAG VFIPSLLIGA AWGRLFGISM SYLTGAAIWA DPGKYALMGA AAQLGGIVRM TLSLTVIMME ATSNVTYGFP IMLVLMTAKI VGDVFIEGLY DMHIQLQSVP FLHWEAPVTS HSLTAREVMS TPVTCLRRRE KVGIIVDVLS DTASNHNGFP VVEDVGDTQP ARLQGLILRS QLIVLLKHKV FVERSNMGLV QRRLRLKDFR DAYPRFPPIQ SIHVSQDERE CTMDLSEFMN PSPYTVPQEA SLPRVFKLFR ALGLRHLVVV DNHNQVVGLV TRKDLARYRL GKGGLEELSL AQT
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
88,731 Da
Sequence Positions
1-803
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P51799
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Clcn7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Clcn7. It may not necessarily be applicable to this product.

NCBI GI #
13928770
NCBI GeneID
29233
NCBI Accession #
NP_113756.1
UniProt Primary Accession #
P51799
UniProt Related Accession #
P51799
GenBank Nucleotide #
NM_031568.2
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 7
NCBI Official Synonym Full Names
chloride voltage-gated channel 7
NCBI Official Symbol
Clcn7
NCBI Official Synonym Symbols
ClC-7
UniProt Protein Name
H(+)/Cl(-) exchange transporter 7
UniProt Synonym Protein Names
Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7
Protein Family
H(+)/Cl(-) exchange transporter
UniProt Gene Name
Clcn7
UniProt Synonym Gene Names
ClC-7
NCBI Protein Information
H(+)/Cl(-) exchange transporter 7

NCBI Summary for Clcn7

putative voltage-gated chloride channel; mutation in human and mouse homologs is associated with osteopetrosis and retinal degeneration [RGD, Feb 2006]

UniProt Comments for Clcn7

Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen.

Research Articles on Clcn7

1. G213R mutation prevents ClC-7 from being correctly targeted to the lysosomal membrane.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with Clcn7 recombinant protein

 Disease Name  Pubmed Publications
 Osteopetrosis Antibodies  >63 publications with Clcn7 and Osteopetrosis
 Disease Models, Animal Antibodies  >9 publications with Clcn7 and Disease Models, Animal
 Brain Diseases Antibodies  >6 publications with Clcn7 and Brain Diseases
 Kidney Diseases Antibodies  >5 publications with Clcn7 and Kidney Diseases
 Anemia Antibodies  >4 publications with Clcn7 and Anemia
 Atrophy Antibodies  >3 publications with Clcn7 and Atrophy
 Thrombocytopenia Antibodies  >3 publications with Clcn7 and Thrombocytopenia
 OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4 Antibodies  >3 publications with Clcn7 and OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4
 Seizures Antibodies  >2 publications with Clcn7 and Seizures
 Lung Diseases Antibodies  >2 publications with Clcn7 and Lung Diseases

Organs/Tissues associated with Clcn7 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with Clcn7 and Brain
 Kidney Antibodies  >10 publications with Clcn7 and Kidney
 Liver Antibodies  >4 publications with Clcn7 and Liver
 Pancreas Antibodies  >1 publications with Clcn7 and Pancreas
 Spleen Antibodies  >1 publications with Clcn7 and Spleen
 Lung Antibodies  >1 publications with Clcn7 and Lung
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