Human IRX5 Recombinant Protein – Cat# MBS718206

Iroquois-Class Homeodomain Protein IRX-5 (IRX5) Human Recombinant Protein

Name: IRX5 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS718206
Price: 1265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718206

MBS718206 is a recombinant protein targeting IRX5. Also known as Recombinant Human Iroquois-class homeodomain protein IRX-5 (IRX5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1265 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Iroquois-class homeodomain protein IRX-5 (IRX5), Recombinant Protein

Full Product Name

Recombinant Human Iroquois-class homeodomain protein IRX-5 (IRX5)

Product Gene Name

IRX5 recombinant protein

Sequence

MSYPQGYLYQ PSASLALYSC PAYSTSVISG PRTDELGRSS SGSAFSPYAG STAFTAPSPG YNSHLQYGAD PAAAAAAAFS SYVGSPYDHT PGMAGSLGYH PYAAPLGSYP YGDPAYRKNA TRDATATLKA WLNEHRKNPY PTKGEKIMLA IITKMTLTQV STWFANARRR LKKENKMTWT PRNRSEDEEE EENIDLEKND EDEPQKPEDK GDPEGPEAGG AEQKAASGCE RLQGPPTPAG KETEGSLSDS DFKEPPSEGR LDALQGPPRT GGPSPAGPAA ARLAEDPAPH YPAGAPAPGP HPAAGEVPPG PGGPSVIHSP PPPPPPAVLA KPKLWSLAEI ATSSDKVKDG GGGNEGSPCP PCPGPIAGQA LGGSRASPAP APSRSPSAQC PFPGGTVLSR PLYYTAPFYP GYTNYGSFGH LHGHPGPGPG PTTGPGSHFN GLNQTVLNRA DALAKDPKML RSQSQLDLCK DSPYELKKGM SDI

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

43,693 Da

Sequence Positions

1-483, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

606195

3D Structure

ModBase 3D Structure for P78411

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IRX5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IRX5. It may not necessarily be applicable to this product.

NCBI GI #

356582257

NCBI GeneID

10265

NCBI Accession #

NP_001239126.1

UniProt Primary Accession #

P78411

UniProt Secondary Accession #

P78416; Q7Z2E1; H0YMS7

UniProt Related Accession #

P78411

GenBank Nucleotide #

NM_001252197.1

NCBI Official Full Name

iroquois-class homeodomain protein IRX-5 isoform 2

NCBI Official Synonym Full Names

iroquois homeobox 5

NCBI Official Symbol

IRX5

NCBI Official Synonym Symbols

HMMS; IRXB2; IRX-2a

UniProt Protein Name

Iroquois-class homeodomain protein IRX-5

UniProt Synonym Protein Names

Homeodomain protein IRX-2A; Homeodomain protein IRXB2; Iroquois homeobox protein 5

Protein Family

Iroquois-class homeodomain protein

UniProt Gene Name

IRX5

UniProt Synonym Gene Names

IRX2A; IRXB2

NCBI Protein Information

iroquois-class homeodomain protein IRX-5

NCBI Summary for IRX5

This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

UniProt Comments for IRX5

Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.

Research Articles on IRX5

1. Authors identify a novel association that implicates the IRX5 gene region in obesity and compare our results with previously derived interaction data for the region.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IRX5 recombinant protein

Reference Product	PubMed Publications
SHH recombinant protein	>3 publications with IRX5 and SHH
VSX1 recombinant protein	>2 publications with IRX5 and VSX1
KCND2 recombinant protein	>2 publications with IRX5 and KCND2

Diseases associated with IRX5 recombinant protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>5 publications with IRX5 and Congenital Abnormalities
Abnormalities, Multiple Antibodies	>3 publications with IRX5 and Abnormalities, Multiple
Hypertrophy Antibodies	>2 publications with IRX5 and Hypertrophy
Cardiovascular Abnormalities Antibodies	>2 publications with IRX5 and Cardiovascular Abnormalities
Genital Diseases, Male Antibodies	>2 publications with IRX5 and Genital Diseases, Male
Heart Defects, Congenital Antibodies	>2 publications with IRX5 and Heart Defects, Congenital
Prostatic Diseases Antibodies	>1 publications with IRX5 and Prostatic Diseases
Disease Models, Animal Antibodies	>1 publications with IRX5 and Disease Models, Animal
Ovarian Diseases Antibodies	>1 publications with IRX5 and Ovarian Diseases
Weight Loss Antibodies	>1 publications with IRX5 and Weight Loss

Organs/Tissues associated with IRX5 recombinant protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>8 publications with IRX5 and Embryonic Tissue
Brain Antibodies	>6 publications with IRX5 and Brain
Bone Antibodies	>5 publications with IRX5 and Bone
Kidney Antibodies	>2 publications with IRX5 and Kidney
Lung Antibodies	>2 publications with IRX5 and Lung