Rat AGTR2 Recombinant Protein – Cat# MBS718350

Type-2 Angiotensin II Receptor (AGTR2) Rat Recombinant Protein

Name: AGTR2 Recombinant Protein; Type-2 Angiotensin II Receptor; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS718350
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718350

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Type-2 angiotensin II receptor (Agtr2), Recombinant Protein

Full Product Name

Recombinant Rat Type-2 angiotensin II receptor

Product Gene Name

Agtr2 recombinant protein

Product Synonym Names

Angiotensin II type-2 receptor; AT2

Sequence

MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

31.9 kDa

Sequence Positions

1-45aa; Extracellular Domain

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P35351

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Agtr2 recombinant protein

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., Inagami T.J. Biol. Chem. 268:24543-24546(1993) Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., Dzau V.J.J. Biol. Chem. 268:24539-24542(1993) Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene.Koike G., Winer E.S., Horiuchi M., Brown D.M., Szpirer C., Dzau V.J., Jacob H.J.Hypertension 26:998-1002(1995) Cloning, expression and regulation of angiotensin II receptors.Inagami T., Iwai N., Sasaki K., Yamano Y., Bardhan S., Chaki S., Guo D.F., Furuta H., Ohyama K., Kambayashi Y., Takahashi K., Ichiki T.Eur. Heart J. 15:104-107(1994) Cloning of the rat angiotensin II type 2 receptor gene and identification of its functional promoter region.Kobayashi S., Ohnishi J., Nibu Y., Nishimatsu S., Umemura S., Ishii M., Murakami K., Miyazaki H.Biochim. Biophys. Acta 1262:155-158(1995) Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange.Feng Y.H., Saad Y., Karnik S.S.FEBS Lett. 484:133-138(2000)

Other Notes

Small volumes of Agtr2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Agtr2 purchase

MBS718350 is a recombinant protein targeting Agtr2. Also known as Recombinant Rat Type-2 angiotensin II receptor. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Agtr2. It may not necessarily be applicable to this product.

NCBI GI #

6978473

NCBI GeneID

24182

NCBI Accession #

NP_036626.1

UniProt Primary Accession #

P35351

UniProt Related Accession #

P35351

GenBank Nucleotide #

NM_012494.3

NCBI Official Full Name

type-2 angiotensin II receptor

NCBI Official Synonym Full Names

angiotensin II receptor, type 2

NCBI Official Symbol

Agtr2

NCBI Official Synonym Symbols

AT2R; AT2-R; AT<sub>2</sub>R

UniProt Protein Name

Type-2 angiotensin II receptor

UniProt Synonym Protein Names

Angiotensin II type-2 receptor; AT2

Protein Family

Type-2 angiotensin II receptor

UniProt Gene Name

Agtr2

UniProt Synonym Gene Names

AT2

UniProt Entry Name

AGTR2_RAT

NCBI Protein Information

type-2 angiotensin II receptor

NCBI Summary for Agtr2

receptor for angiotensin II; vasodilator that regulates many actions in vascular smooth muscle cells and during development [RGD, Feb 2006]

UniProt Comments for Agtr2

AT2: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: integral to membrane; intracellular; perinuclear region of cytoplasm; plasma membrane

Molecular Function: angiotensin type II receptor activity; G-protein alpha-subunit binding; peptide hormone binding; protein binding; transcription factor binding

Biological Process: angiotensin mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; cell surface receptor linked signal transduction; cellular sodium ion homeostasis; cerebellar cortex development; dopamine biosynthetic process; G-protein signaling, coupled to cGMP nucleotide second messenger; inflammatory response; kidney development; negative regulation of fibroblast proliferation; negative regulation of heart rate; negative regulation of icosanoid secretion; negative regulation of nerve growth factor receptor signaling pathway; negative regulation of neuron apoptosis; neuron differentiation; positive regulation of cell proliferation; positive regulation of cytokine secretion; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; regulation of transcription factor import into nucleus; renin-angiotensin regulation of aldosterone production; response to organic nitrogen

Research Articles on Agtr2

1. Stress and stress plus ethanol may alter endothelial signaling via AT2-receptors, and thereby increase blood pressure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Agtr2 recombinant protein

Reference Product	PubMed Publications
Agt recombinant protein	>59 publications with Agtr2 and Agt
Cxcl12 recombinant protein	>1 publications with Agtr2 and Cxcl12

Pathways associated with Agtr2 recombinant protein

Products by Pathway	Pathway Diagram
ACE Inhibitor Pathway antibodies	ACE Inhibitor Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with Agtr2 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>1072 publications with Agtr2 and Cardiovascular Diseases
Hypertension Antibodies	>901 publications with Agtr2 and Hypertension
Heart Diseases Antibodies	>484 publications with Agtr2 and Heart Diseases
Hypertrophy Antibodies	>297 publications with Agtr2 and Hypertrophy
Kidney Diseases Antibodies	>278 publications with Agtr2 and Kidney Diseases
Disease Models, Animal Antibodies	>236 publications with Agtr2 and Disease Models, Animal
Heart Failure Antibodies	>186 publications with Agtr2 and Heart Failure
Fibrosis Antibodies	>171 publications with Agtr2 and Fibrosis
Cardiomegaly Antibodies	>161 publications with Agtr2 and Cardiomegaly
Myocardial Infarction Antibodies	>159 publications with Agtr2 and Myocardial Infarction

Organs/Tissues associated with Agtr2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>685 publications with Agtr2 and Kidney
Artery Antibodies	>536 publications with Agtr2 and Artery
Brain Antibodies	>356 publications with Agtr2 and Brain
Ovary Antibodies	>44 publications with Agtr2 and Ovary
Spleen Antibodies	>10 publications with Agtr2 and Spleen