Molecular cloning and characterization of the human E-cadherin cDNA.Bussemakers M.J.G., Mees S.G.M., van Bokhoven A., Debruyne F.M.J., Schalken J.A.Mol. Biol. Rep. 17:123-128(1993)
E-cadherin gene mutations in human gastric carcinoma cell lines.Oda T., Kanai Y., Oyama T., Yoshiura K., Shimoyama Y., Birchmeier W., Sugimura T., Hirohashi S.Proc. Natl. Acad. Sci. U.S.A. 91:1858-1862(1994)
Molecular cloning of human E-cadherin suggests a novel subdivision of the cadherin superfamily.Rimm D.L., Morrow J.S.Biochem. Biophys. Res. Commun. 200:1754-1761(1994)
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts.Ito K., Okamoto I., Araki N., Kawano Y., Nakao M., Fujiyama S., Tomita K., Mimori T., Saya H.Oncogene 18:7080-7090(1999)
Mutant E-cadherin.Shibamoto S., Fukudome Y., Yanagihara K.Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.Nat. Genet. 36:40-45(2004)
NIEHS SNPs programThe sequence and analysis of duplication-rich human chromosome 16.Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.Nature 432:988-994(2004)
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines
characterization of the human E-cadherin gene promoter.Bussemakers M.J.G., Giroldi L.A., van Bokhoven A., Schalken J.A.Biochem. Biophys. Res. Commun. 203:1284-1290(1994)
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.Yoshiura K., Kanai Y., Ochiai A., Shimoyama Y., Sugimura T., Hirohashi S.Proc. Natl. Acad. Sci. U.S.A. 92:7416-7419(1995)
Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin.Ling K., Bairstow S.F., Carbonara C., Turbin D.A., Huntsman D.G., Anderson R.A.J. Cell Biol. 176:343-353(2007)
Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1)
.Berx G., Staes K., van Hengel J., Molemans F., Bussemakers M.J.G., van Bokhoven A., van Roy F.Genomics 26:281-289(1995)
Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.Mansouri A., Spurr N., Goodfellow P.N., Kemler R.Differentiation 38:67-71(1988)
Frixen U.H. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.Becker K.-F., Atkinson M.J., Reich U., Becker I., Nekarda H., Siewert J.R., Hoefler H.Cancer Res. 54:3845-3852(1994)
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Marambaud P., Shioi J., Serban G., Georgakopoulos A., Sarner S., Nagy V., Baki L., Wen P., Efthimiopoulos S., Shao Z., Wisniewski T., Robakis N.K.EMBO J. 21:1948-1956(2002)
Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.Ozawa M., Ringwald M., Kemler R.Proc. Natl. Acad. Sci. U.S.A. 87:4246-4250(1990)
Distinct cadherin-catenin complexes in Ca(2+)
-dependent cell-cell adhesion.Butz S., Kemler R.FEBS Lett. 355:195-200(1994)
Cleavage and shedding of E-cadherin after induction of apoptosis.Steinhusen U., Weiske J., Badock V., Tauber R., Bommert K., Huber O.J. Biol. Chem. 276:4972-4980(2001)
Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.Baki L., Marambaud P., Efthimiopoulos S., Georgakopoulos A., Wen P., Cui W., Shioi J., Koo E., Ozawa M., Friedrich V.L., Robakis N.K.Proc. Natl. Acad. Sci. U.S.A. 98:2381-2386(2001)
Disulfide bond formation promotes the cis- and trans-dimerization of the E-cadherin-derived first repeat.Makagiansar I.T., Nguyen P.D., Ikesue A., Kuczera K., Dentler W., Urbauer J.L., Galeva N., Alterman M., Siahaan T.J.J. Biol. Chem. 277:16002-16010(2002)
Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells.Laprise P., Viel A., Rivard N.J. Biol. Chem. 279:10157-10166(2004)
Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells.Bharti S., Handrow-Metzmacher H., Zickenheiner S., Zeitvogel A., Baumann R., Starzinski-Powitz A.Mol. Biol. Cell 15:397-406(2004)
Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.Serban G., Kouchi Z., Baki L., Georgakopoulos A., Litterst C.M., Shioi J., Robakis N.K.J. Biol. Chem. 280:36007-36012(2005)
Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin.Lock J.G., Stow J.L.Mol. Biol. Cell 16:1744-1755(2005)
The cytoplasmic sequence of E-cadherin promotes non-amyloidogenic degradation of A beta precursors.Agiostratidou G., Muros R.M., Shioi J., Marambaud P., Robakis N.K.J. Neurochem. 96:1182-1188(2006)
Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin.Meng Y.G., Han W.-D., Zhao Y.-L., Huang K., Si Y.-L., Wu Z.-Q., Mu Y.-M.Cell Res. 17:869-880(2007)
Germline E-cadherin mutations in familial lobular breast cancer.Masciari S., Larsson N., Senz J., Boyd N., Kaurah P., Kandel M.J., Harris L.N., Pinheiro H.C., Troussard A., Miron P., Tung N., Oliveira C., Collins L., Schnitt S., Garber J.E., Huntsman D.J. Med. Genet. 44:726-731(2007)
Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD.Zhou F., Su J., Fu L., Yang Y., Zhang L., Wang L., Zhao H., Zhang D., Li Z., Zha X.Glycoconj. J. 25:727-740(2008)
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.Abe K., Takeichi M.Proc. Natl. Acad. Sci. U.S.A. 105:13-19(2008)
Structure and biochemistry of cadherins and catenins.Shapiro L., Weis W.I.Cold Spring Harb. Perspect. Biol. 1:A3053-A3053(2009)
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation.Frasa M.A., Maximiano F.C., Smolarczyk K., Francis R.E., Betson M.E., Lozano E., Goldenring J., Seabra M.C., Rak A., Ahmadian M.R., Braga V.M.Curr. Biol. 20:198-208(2010)
DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.Eswaramoorthy R., Wang C.K., Chen W.C., Tang M.J., Ho M.L., Hwang C.C., Wang H.M., Wang C.Z.J. Cell. Physiol. 224:387-397(2010)
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis.Zhou W.J., Geng Z.H., Chi S., Zhang W., Niu X.F., Lan S.J., Ma L., Yang X., Wang L.J., Ding Y.Q., Geng J.G.Cell Res. 21:609-626(2011)
Acetylation-dependent regulation of Skp2 function.Inuzuka H., Gao D., Finley L.W., Yang W., Wan L., Fukushima H., Chin Y.R., Zhai B., Shaik S., Lau A.W., Wang Z., Gygi S.P., Nakayama K., Teruya-Feldstein J., Toker A., Haigis M.C., Pandolfi P.P., Wei W.Cell 150:179-193(2012)
Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin.Mukherjee M., Chow S.Y., Yusoff P., Seetharaman J., Ng C., Sinniah S., Koh X.W., Asgar N.F., Li D., Yim D., Jackson R.A., Yew J., Qian J., Iyu A., Lim Y.P., Zhou X., Sze S.K., Guy G.R., Sivaraman J.EMBO J. 31:1308-1319(2012)
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)
Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.Schubert W.-D., Urbanke C., Ziehm T., Beier V., Machner M.P., Domann E., Wehland J., Chakraborty T., Heinz D.W.Cell 111:825-836(2002)
Mutations of the human E-cadherin (CDH1)
gene.Berx G., Becker K.-F., Hoefler H., van Roy F.3.0.CO;2-D>Hum. Mutat. 12:226-237(1998)
The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism.Parisini E., Higgins J.M., Liu J.H., Brenner M.B., Wang J.H.J. Mol. Biol. 373:401-411(2007)
Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition.Li Y., Hofmann M., Wang Q., Teng L., Chlewicki L.K., Pircher H., Mariuzza R.A.Immunity 31:35-46(2009)
Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast.Kanai Y., Oda T., Tsuda H., Ochiai A., Hirohashi S.Jpn. J. Cancer Res. 85:1035-1039(1994)
Mutations of the E-cadherin gene in human gynecologic cancers.Risinger J.I., Berchuck A., Kohler M.F., Boyd J.Nat. Genet. 7:98-102(1994)
E-cadherin gene mutations in signet ring cell carcinoma of the stomach.Muta H., Noguchi M., Kanai Y., Ochiai A., Nawata H., Hirohashi S.Jpn. J. Cancer Res. 87:843-848(1996)
Inactivation of the E-cadherin gene in primary gastric carcinomas and gastric carcinoma cell lines.Tamura G., Sakata K., Nishizuka S., Maesawa C., Suzuki Y., Iwaya T., Terashima M., Saito K., Satodate R.Jpn. J. Cancer Res. 87:1153-1159(1996)
E-cadherin gene alterations are rare events in thyroid tumors.Soares P., Berx G., van Roy F., Sobrinho-Simoes M.3.0.CO;2-7>Int. J. Cancer 70:32-38(1997)
E-cadherin germline mutations in familial gastric cancer.Guilford P.J., Hopkins J.B.W., Harraway J., McLeod M., McLeod N., Harawira P., Taite H., Scoular R., Miller A., Reeve A.E.Nature 392:402-405(1998)
Germline mutations of E-cadherin gene in Korean familial gastric cancer patients.Yoon K.-A., Ku J.-L., Yang H.-K., Kim W.H., Park S.Y., Park J.-G.J. Hum. Genet. 44:177-180(1999)
The E-cadherin gene (CDH1)
variants T340A and L599V in gastric and colorectal cancer patients in Korea.Kim H.C., Wheeler J.M.D., Kim J.C., Ilyas M., Beck N.E., Kim B.S., Park K.C., Bodmer W.F.Gut 47:262-267(2000)
Association of E-cadherin germ-line alterations with prostate cancer.Ikonen T., Matikainen M., Mononen N., Hyytinen E.R., Helin H.J., Tommola S., Tammela T.L., Pukkala E., Schleutker J., Kallioniemi O.-P., Koivisto P.A.Clin. Cancer Res. 7:3465-3471(2001)
A germline E-cadherin mutation in a family with gastric and colon cancer.Salahshor S., Hou H., Diep C.B., Loukola A., Zhang H., Liu T., Chen J., Iselius L., Rubio C., Lothe R.A., Aaltonen L., Sun X.F., Lindmark G., Lindblom A.Int. J. Mol. Med. 8:439-443(2001)
Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred.Oliveira C., Bordin M.C., Grehan N., Huntsman D., Suriano G., Machado J.C., Kiviluoto T., Aaltonen L., Jackson C.E., Seruca R., Caldas C.Hum. Mutat. 19:510-517(2002)
E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer.Yabuta T., Shinmura K., Tani M., Yamaguchi S., Yoshimura K., Katai H., Nakajima T., Mochiki E., Tsujinaka T., Takami M., Hirose K., Yamaguchi A., Takenoshita S., Yokota J.Int. J. Cancer 101:434-441(2002)
Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands.Suriano G., Oliveira C., Ferreira P., Machado J.C., Bordin M.C., De Wever O., Bruyneel E.A., Moguilevsky N., Grehan N., Porter T.R., Richards F.M., Hruban R.H., Roviello F., Huntsman D., Mareel M., Carneiro F., Caldas C., Seruca R.Hum. Mol. Genet. 12:575-582(2003)
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas.Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.Breast Cancer Res. 9:R5-R5(2007)
+Additional computationally mapped references.<p>Provides general information on the entry.
ELISA Kit
CLIA Kit
Assay Kit
Antibodies
Polyclonal Antibody
Secondary Antibody
Antigen
Biochemical
cDNA Clone
siRNA
Peptide
Rec./Purified Protein
Custom ELISA Kit
Custom Protein
Custom Antibody
Antibody Matched Pairs
Antibody Peptide Pairs
Phospho Antibodies
Products by Disease
Products by Pathway
Products by Tissue