Potassium Voltage-Gated Channel Subfamily A Member 1 (KCNA1) Rat Recombinant Protein

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heterotetramer of potassium channel proteins. Binds KCNAB2

By similarity. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1. Ref.4 Ref.5 Ref.6

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Post-translational modification: Palmitoylated on Cys-243; which may be required for membrane targeting

By similarity.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. [View classification]

RNA editing: Edited at position 400.Partially edited. RNA editing is at an average of 50% in the whole brain. Ref.3