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Endoplasmic Reticulum Chaperone Bip (HSPA5) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718537

MBS718537 is a recombinant protein targeting Hspa5. Also known as Recombinant Mouse Endoplasmic reticulum chaperone BiP (Hspa5). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Endoplasmic reticulum chaperone BiP (Hspa5), Recombinant Protein
Full Product Name
Recombinant Mouse Endoplasmic reticulum chaperone BiP (Hspa5)
Product Gene Name
Hspa5 recombinant protein
Sequence
EEEDKKEDVG TVVGIDLGTT YSCVGVFKNG RVEIIANDQG NRITPSYVAF TPEGERLIGD AAKNQLTSNP ENTVFDAKRL IGRTWNDPSV QQDIKFLPFK VVEKKTKPYI QVDIGGGQTK TFAPEEISAM VLTKMKETAE AYLGKKVTHA VVTVPAYFND AQRQATKDAG TIAGLNVMRI INEPTAAAIA YGLDKREGEK NILVFDLGGG TFDVSLLTID NGVFEVVATN GDTHLGGEDF DQRVMEHFIK LYKKKTGKDV RKDNRAVQKL RREVEKAKRA LSSQHQARIE IESFFEGEDF SETLTRAKFE ELNMDLFRST MKPVQKVLED SDLKKSDIDE IVLVGGSTRI PKIQQLVKEF FNGKEPSRGI NPDEAVAYGA AVQAGVLSGD QDTGDLVLLD VCPLTLGIET VGGVMTKLIP RNTVVPTKKS QIFSTASDNQ PTVTIKVYEG ERPLTKDNHL LGTFDLTGIP PAPRGVPQIE VTFEIDVNGI LRVTAEDKGT GNKNKITITN DQNRLTPEEI ERMVNDAEKF AEEDKKLKER IDTRNELESY AYSLKNQIGD KEKLGGKLSS EDKETMEKAV EEKIEWLESH QDADIEDFKA KKKELEEIVQ PIISKLYGSG GPPPTGEEDT SEKDEL
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
72.5 kDa
Sequence Positions
20-655aa; Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P20029
Species
Mouse
Production Note
Special Offer: The E Coli, Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Coli, Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli, Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli, Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Hspa5 recombinant protein

Mouse HSPA5 Recombinant Protein – Cat# MBS718537

Other Notes

Small volumes of Hspa5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Hspa5. It may not necessarily be applicable to this product.

NCBI GI #
254540168
NCBI GeneID
14828
NCBI Accession #
NP_001156906.1
UniProt Primary Accession #
P20029
UniProt Secondary Accession #
O35642; Q3UFF2; Q61630
UniProt Related Accession #
P20029
GenBank Nucleotide #
NM_001163434.1
NCBI Official Full Name
78 kDa glucose-regulated protein
NCBI Official Synonym Full Names
heat shock protein 5
NCBI Official Symbol
Hspa5
NCBI Official Synonym Symbols
Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; AL022860; AU019543; D2Wsu17e; D2Wsu141e
UniProt Protein Name
Endoplasmic reticulum chaperone BiP
UniProt Synonym Protein Names
78 kDa glucose-regulated protein
UniProt Gene Name
Hspa5
UniProt Synonym Gene Names
HSP70 family protein 5Curated
NCBI Protein Information
78 kDa glucose-regulated protein

UniProt Comments for Hspa5

Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:12411443, PubMed:12475965). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (PubMed:12411443). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 ().
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Research Articles on Hspa5

1. analysis of the effects of triptolide on cell proliferation, cell cycle and the expression of GRP78 in nasopharyngeal carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Hspa5 recombinant protein

 Reference Product  PubMed Publications
 Atf6 recombinant protein  >43 publications with Hspa5 and Atf6
 Ern1 recombinant protein  >12 publications with Hspa5 and Ern1
 Hsp90b1 recombinant protein  >12 publications with Hspa5 and Hsp90b1
 Ern2 recombinant protein  >8 publications with Hspa5 and Ern2
 Hsp90aa1 recombinant protein  >6 publications with Hspa5 and Hsp90aa1
 Hsp90ab1 recombinant protein  >4 publications with Hspa5 and Hsp90ab1

Pathways associated with Hspa5 recombinant protein

 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram
 Protein Export Pathway antibodies  Protein Export Pathway Diagram

Diseases associated with Hspa5 recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >92 publications with Hspa5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >87 publications with Hspa5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >86 publications with Hspa5 and Nervous System Diseases
 Inflammation Antibodies  >47 publications with Hspa5 and Inflammation
 Heart Diseases Antibodies  >32 publications with Hspa5 and Heart Diseases
 Necrosis Antibodies  >31 publications with Hspa5 and Necrosis
 Liver Diseases Antibodies  >30 publications with Hspa5 and Liver Diseases
 Kidney Diseases Antibodies  >18 publications with Hspa5 and Kidney Diseases
 Obesity Antibodies  >14 publications with Hspa5 and Obesity
 Fibrosis Antibodies  >14 publications with Hspa5 and Fibrosis

Organs/Tissues associated with Hspa5 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >110 publications with Hspa5 and Brain
 Muscle Antibodies  >75 publications with Hspa5 and Muscle
 Blood Antibodies  >69 publications with Hspa5 and Blood
 Heart Antibodies  >60 publications with Hspa5 and Heart
 Liver Antibodies  >53 publications with Hspa5 and Liver
 Kidney Antibodies  >45 publications with Hspa5 and Kidney
 Artery Antibodies  >30 publications with Hspa5 and Artery
 Pancreas Antibodies  >24 publications with Hspa5 and Pancreas
 Lung Antibodies  >23 publications with Hspa5 and Lung
 Ovary Antibodies  >15 publications with Hspa5 and Ovary
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