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Potassium Voltage-Gated Channel Subfamily A Member 3 (KCNA3) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718598

MBS718598 is a recombinant protein targeting Kcna3. Also known as Recombinant Rat Potassium voltage-gated channel subfamily A member 3 (Kcna3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$825 / 0.05 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Potassium voltage-gated channel subfamily A member 3 (Kcna3), Recombinant Protein
Full Product Name
Recombinant Rat Potassium voltage-gated channel subfamily A member 3 (Kcna3)
Product Gene Name
Kcna3 recombinant protein
Product Synonym Gene Name
Kcna3
Product Synonym Names
Recombinant Potassium voltage-gated channel subfamily A member 3 (Kcna3); Potassium voltage-gated channel subfamily A member 3; RCK3 RGK5 Voltage-gated potassium channel subunit Kv1.3 Voltage-gated potassium channel subunit Kv3
Sequence
MTVVPGDHLL EPEAAGGGGG DPPQGGCVSG GGCDRYEPLP PALPAAGEQD CCGERVVINI SGLRFETQLK TLCQFPETLL GDPKRRMRYF DPLRNEYFFD R NRPSFDA ILYYYQSGGR IRRPVNVPID IFSEEIRFYQ LGEEAMEKFR EDEGFLREEE RPLPRRDFQR QVWLLFEYPE SSGPAR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
58,425 Da
Sequence Positions
: 1-184. Partial.
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 2; NC_005101.3 (229233084..229234661). Location: 2q34
3D Structure
ModBase 3D Structure for P15384
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Kcna3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcna3. It may not necessarily be applicable to this product.

NCBI GI #
148298869
NCBI GeneID
29731
NCBI Accession #
NP_062143.3
UniProt Primary Accession #
P15384
UniProt Related Accession #
P15384
GenBank Nucleotide #
NM_019270.3
NCBI Official Full Name
potassium voltage-gated channel subfamily A member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel, shaker-related subfamily, member 3
NCBI Official Symbol
Kcna3
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 3
UniProt Synonym Protein Names
RCK3; RGK5; Voltage-gated potassium channel subunit Kv1.3; Voltage-gated potassium channel subunit Kv3
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
Kcna3
UniProt Entry Name
KCNA3_RAT
NCBI Protein Information
potassium voltage-gated channel subfamily A member 3; KV3; RCK3; RGK5; voltage-gated potassium channel subunit Kv3; voltage-gated potassium channel subunit Kv1.3; potassium voltage gated channel, shaker related subfamily, member 3

NCBI Summary for Kcna3

encodes a lymphocyte potassium channel [RGD, Feb 2006]

UniProt Comments for Kcna3

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heterotetramer of potassium channel proteins

By similarity. Binds PDZ domains of DLG1, DLG2 and DLG4.

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. [View classification]
Show more

Research Articles on Kcna3

1. Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.(

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Kcna3 recombinant protein

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with Kcna3 recombinant protein

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >11 publications with Kcna3 and Brain Diseases
 Necrosis Antibodies  >7 publications with Kcna3 and Necrosis
 Drug Toxicity Antibodies  >6 publications with Kcna3 and Drug Toxicity
 Memory Disorders Antibodies  >5 publications with Kcna3 and Memory Disorders
 Inflammation Antibodies  >5 publications with Kcna3 and Inflammation
 Neurologic Manifestations Antibodies  >4 publications with Kcna3 and Neurologic Manifestations
 Hyperplasia Antibodies  >3 publications with Kcna3 and Hyperplasia
 Cardiovascular Diseases Antibodies  >3 publications with Kcna3 and Cardiovascular Diseases
 Coma Antibodies  >2 publications with Kcna3 and Coma
 Vascular Diseases Antibodies  >2 publications with Kcna3 and Vascular Diseases

Organs/Tissues associated with Kcna3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >41 publications with Kcna3 and Brain
 Testis Antibodies  >2 publications with Kcna3 and Testis
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