Mouse RNF19B Recombinant Protein – Cat# MBS718606

E3 Ubiquitin-Protein Ligase RNF19B (RNF19B) Mouse Recombinant Protein

Name: RNF19B Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS718606
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718606

MBS718606 is a recombinant protein targeting Rnf19b. Also known as Recombinant Mouse E3 ubiquitin-protein ligase RNF19B (Rnf19b). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Rnf19b; Ibrdc3, Nklam More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

E3 ubiquitin-protein ligase RNF19B (Rnf19b), Recombinant Protein

Full Product Name

Recombinant Mouse E3 ubiquitin-protein ligase RNF19B (Rnf19b)

Product Gene Name

Rnf19b recombinant protein

Product Synonym Gene Name

Recombinant E3 ubiquitin-protein ligase RNF19B (Rnf19b); E3 ubiquitin-protein ligase RNF19B EC= 6.3.2.-; IBR domain-containing protein 3 Natural killer lytic-associated molecule RING finger protein 19B

Sequence

MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTFHSVFS ASARGRRART KPQAEPPPPA APPPPPPPAP APVEAQAPPV EALPSEPAAE AEAEAVAAGP EEDEAAEGGG AEEVECPLCL VRLPPERAPR LLSCPHRSCR DCLRHYLRLE ISESRVPISC PECSERLNPH DIRLLLADPP LMHKYEEFML RRYLASDPDC RWCPAPDCGY AVIAYGCASC PKLTCEREGC QTEFCYHCKQ IWHPNQTCDM ARQQRAQTLR VRTKHTSGLS YGQESGPADD IKPCPRCSAY IIKMNDGSCN HMTCAVCGCE FCWLCMKEIS DLHYLSPSGC TFWGKKPWSR KKKILWQLGT LIGAPVGISL IAGIAIPAMV IGIPVYVGRK IHSRYEGRKT SKHKRNLAIT GGVTLSVIAS PVIAAVSVGI GVPIMLAYVY GVVPISLCRG GGCGVSTANG KGVKIEFDED DGPITVADAW RALKNPSIGE SSIEGLTSVL STSGSPTDGL SVMQGPYSET ASFAALSGGT LSGGILSSGK GKYSRLEVQA DVQKEIFPKD TASLGAISDS ASTRAMAGSI ISSYNPQDRE CNNMEIQVDI EAKPSHYQLV SGSSTEDSLH VHAQVAEKEE EGNGAGGGSG GSEDDPPYKH QSCEQKDCLA SKAWDISLAQ PESIRSDLES SDTQSDDVPD ITSDECGSPR SHAAACPSTP QVHGAPSPSA HKNLAAPAEG QTVLKSEEYE VE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

78,127 Da

Sequence Positions

1-732

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for A2A7Q9

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Rnf19b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Rnf19b. It may not necessarily be applicable to this product.

UniProt Primary Accession #

A2A7Q9

UniProt Secondary Accession #

Q7TT05; A0AUN9

UniProt Protein Name

E3 ubiquitin-protein ligase RNF19B

UniProt Synonym Protein Names

IBR domain-containing protein 3; Natural killer lytic-associated molecule; RING finger protein 19B

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

Rnf19b

UniProt Synonym Gene Names

Ibrdc3; Nklam

UniProt Entry Name

RN19B_MOUSE

UniProt Comments for Rnf19b

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells

By similarity.

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Interacts with UBE2L3, UBE2L6 and UCKL1

By similarity.

Subcellular location: Cytoplasmic granule membrane; Multi-pass membrane protein

By similarity.

Tissue specificity: Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in macrophages (at protein level). Ref.1

Induction: By IFNG and LPS in macrophages. By IL2 in natural killer cells and cytotoxic T-cells. Ref.1

Domain: The first IBR-type zinc finger is the most crucial for interaction with UBE2L3, UBE2L6 and UCKL1

By similarity.

Sequence similarities: Belongs to the RBR family. RNF19 subfamily.Contains 1 IBR-type zinc finger.Contains 2 RING-type zinc fingers.

Sequence caution: The sequence AAH52529.1 differs from that shown. Reason: Erroneous initiation. The sequence CAM19707.1 differs from that shown. Reason: Erroneous initiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.