Human PLCD1 Recombinant Protein – Cat# MBS718827

1-Phosphatidylinositol 4,5-Bisphosphate Phosphodiesterase Delta-1 (PLCD1) Human Recombinant Protein

Name: PLCD1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS718827
Price: 1620 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS718827

MBS718827 is a recombinant protein targeting PLCD1. Also known as Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1620 / 0.02 mg (E-Coli) +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1), Recombinant Protein

Full Product Name

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (PLCD1)

Product Gene Name

PLCD1 recombinant protein

Sequence

MDSGRDFLTL HGLQDDEDLQ ALLKGSQLLK VKSSSWRRER FYKLQEDCKT IWQESRKVMR TPESQLFSIE DIQEVRMGHR TEGLEKFARD VPEDRCFSIV FKDQRNTLDL IAPSPADAQH WVLGLHKIIH HSGSMDQRQK LQHWIHSCLR KADKNKDNKM SFKELQNFLK ELNIQVDDSY ARKIFRECDH SQTDSLEDEE IEAFYKMLTQ RVEIDRTFAE AAGSGETLSV DQLVTFLQHQ QREEAAGPAL ALSLIERYEP SETAKAQRQM TKDGFLMYLL SADGSAFSLA HRRVYQDMGQ PLSHYLVSSS HNTYLLEDQL AGPSSTEAYI RALCKGCRCL ELDCWDGPNQ EPIIYHGYTF TSKILFCDVL RAIRDYAFKA SPYPVILSLE NHCTLEQQRV MARHLHAILG PMLLNRPLDG VTNSLPSPEQ LKGKILLKGK KLGGLLPPGG EGGPEATVVS DEDEAAEMED EAVRSRVQHK PKEDKLRLAQ ELSDMVIYCK SVHFGGFSSP GTPGQAFYEM ASFSENRALR LLQESGNGFV RHNVGHLSRI YPAGWRTDSS NYSPVEMWNG GCQIVALNFQ TPGPEMDVYQ GRFQDNGACG YVLKPAFLRD PNGTFNPRAL AQGPWWARKR LNIRVISGQQ LPKVNKNKNS IVDPKVTVEI HGVSRDVASR QTAVITNNGF NPWWDTEFAF EVVVPDLALI RFLVEDYDAS SKNDFIGQST IPLNSLKQGY RHVHLMSKNG DQHPSATLFV KISLQD

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

88,135 Da

Sequence Positions

1-756, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

151600

3D Structure

ModBase 3D Structure for P51178

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PLCD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PLCD1. It may not necessarily be applicable to this product.

NCBI GI #

195972883

NCBI GeneID

5333

NCBI Accession #

NP_001124436.1

UniProt Primary Accession #

P51178

UniProt Secondary Accession #

Q86VN8; B3KR14

UniProt Related Accession #

P51178

GenBank Nucleotide #

NM_001130964.1

NCBI Official Full Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1

NCBI Official Synonym Full Names

phospholipase C delta 1

NCBI Official Symbol

PLCD1

NCBI Official Synonym Symbols

NDNC3; PLC-III

UniProt Protein Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

UniProt Synonym Protein Names

Phosphoinositide phospholipase C-delta-1; Phospholipase C-III; PLC-III; Phospholipase C-delta-1; PLC-delta-1

Protein Family

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

UniProt Gene Name

PLCD1

UniProt Synonym Gene Names

PLC-III; PLC-delta-1

NCBI Protein Information

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

NCBI Summary for PLCD1

This gene encodes a member of the phospholipase C family. Phospholipase C isozymes play critical roles in intracellular signal transduction by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers diacylglycerol (DAG) and inositol triphosphate (IP3). The encoded protein functions as a tumor suppressor in several types of cancer, and mutations in this gene are a cause of hereditary leukonychia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

UniProt Comments for PLCD1

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.

Research Articles on PLCD1

1. Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLCD1 recombinant protein

Reference Product	PubMed Publications
PLCB2 recombinant protein	>4 publications with PLCD1 and PLCB2
PLCB3 recombinant protein	>3 publications with PLCD1 and PLCB3
PLCG2 recombinant protein	>1 publications with PLCD1 and PLCG2
PLCG1 recombinant protein	>1 publications with PLCD1 and PLCG1

Pathways associated with PLCD1 recombinant protein

Products by Pathway	Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies	D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway antibodies	D-myo-inositol (1,4,5)-trisphosphate Biosynthesis Pathway Diagram
D-myo-inositol-5-phosphate Metabolism Pathway antibodies	D-myo-inositol-5-phosphate Metabolism Pathway Diagram
D-myo-inositol-5-phosphate Metabolism Pathway antibodies	D-myo-inositol-5-phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism Pathway antibodies	Inositol Phosphate Metabolism Pathway Diagram
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies	Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram

Diseases associated with PLCD1 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>11 publications with PLCD1 and Cardiovascular Diseases
Heart Diseases Antibodies	>9 publications with PLCD1 and Heart Diseases
Hypertension Antibodies	>4 publications with PLCD1 and Hypertension
Hypertrophy Antibodies	>3 publications with PLCD1 and Hypertrophy
Disease Models, Animal Antibodies	>3 publications with PLCD1 and Disease Models, Animal
Hyperplasia Antibodies	>2 publications with PLCD1 and Hyperplasia
Weight Loss Antibodies	>2 publications with PLCD1 and Weight Loss
Lung Neoplasms Antibodies	>2 publications with PLCD1 and Lung Neoplasms
Myocardial Infarction Antibodies	>2 publications with PLCD1 and Myocardial Infarction
Ventricular Dysfunction, Left Antibodies	>2 publications with PLCD1 and Ventricular Dysfunction, Left

Organs/Tissues associated with PLCD1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>16 publications with PLCD1 and Brain
Blood Antibodies	>15 publications with PLCD1 and Blood
Heart Antibodies	>14 publications with PLCD1 and Heart
Liver Antibodies	>10 publications with PLCD1 and Liver
Muscle Antibodies	>9 publications with PLCD1 and Muscle
Kidney Antibodies	>9 publications with PLCD1 and Kidney
Skin Antibodies	>8 publications with PLCD1 and Skin
Lung Antibodies	>7 publications with PLCD1 and Lung
Vascular Antibodies	>6 publications with PLCD1 and Vascular
Embryonic Tissue Antibodies	>5 publications with PLCD1 and Embryonic Tissue