Mad-related genes in the human.Riggins G.J., Thiagalingam S., Rosenblum E., Weinstein C.L., Kern S.E., Hamilton S.R., Willson J.K.V., Markowitz S.D., Kinzler K.W., Vogelstein B.V.Nat. Genet. 13:347-349(1996)
Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.Zhang Y., Feng X.-H., Wu R.-Y., Derynck R.Nature 383:168-172(1996)
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.Eppert K., Scherer S.W., Ozcelik H., Pirone R., Hoodless P., Kim H., Tsui L.-C., Bapat B., Gallinger S., Andrulis I.L., Thomsen G.H., Wrana J.L., Attisano L.Cell 86:543-552(1996)
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.Liu F., Pouponnot C., Massague J.Genes Dev. 11:3157-3167(1997)
Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway.Takenoshita S., Mogi A., Nagashima M., Yang K., Yagi K., Hanyu A., Nagamachi Y., Miyazono K., Hagiwara K.Genomics 48:1-11(1998)
Bienvenut W.V., von Kriegsheim A., Kolch W.Submitted (DEC-2008)
to UniProtKB
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.Macias-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., Wrana J.L.Cell 87:1215-1224(1996)
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., Wrana J.L.Cell 95:779-791(1998)
Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.Kawabata M., Inoue H., Hanyu A., Imamura T., Miyazono K.EMBO J. 17:4056-4065(1998)
Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.Yagi K., Goto D., Hamamoto T., Takenoshita S., Kato M., Miyazono K.J. Biol. Chem. 274:703-709(1999)
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.Kretzschmar M., Liu F., Hata A., Doody J., Massague J.Genes Dev. 11:984-995(1997)
TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.Abdollah S., Macias-Silva M., Tsukazaki T., Hayashi H., Attisano L., Wrana J.L.J. Biol. Chem. 272:27678-27685(1997)
Characterization of human FAST-1, a TGF beta and activin signal transducer.Zhou S., Zawel L., Lengauer C., Kinzler K.W., Vogelstein B.Mol. Cell 2:121-127(1998)
Roles of pathway-specific and inhibitory Smads in activin receptor signaling.Lebrun J.J., Takabe K., Chen Y., Vale W.Mol. Endocrinol. 13:15-23(1999)
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.Hocevar B.A., Smine A., Xu X.X., Howe P.H.EMBO J. 20:2789-2801(2001)
Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription.Leong G.M., Subramaniam N., Figueroa J., Flanagan J.L., Hayman M.J., Eisman J.A., Kouzmenko A.P.J. Biol. Chem. 276:18243-18248(2001)
TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.Bonni S., Wang H.R., Causing C.G., Kavsak P., Stroschein S.L., Luo K., Wrana J.L.Nat. Cell Biol. 3:587-595(2001)
Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.Abdel-Wahab N., Wicks S.J., Mason R.M., Chantry A.Biochem. J. 362:643-649(2002)
Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase.Funaba M., Zimmerman C.M., Mathews L.S.J. Biol. Chem. 277:41361-41368(2002)
MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.Lin F., Morrison J.M., Wu W., Worman H.J.Hum. Mol. Genet. 14:437-445(2005)
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.Pan D., Estevez-Salmeron L.D., Stroschein S.L., Zhu X., He J., Zhou S., Luo K.J. Biol. Chem. 280:15992-16001(2005)
Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.Arndt S., Poser I., Schubert T., Moser M., Bosserhoff A.-K.Lab. Invest. 85:1330-1341(2005)
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.Lin X., Duan X., Liang Y.Y., Su Y., Wrighton K.H., Long J., Hu M., Davis C.M., Wang J., Brunicardi F.C., Shi Y., Chen Y.G., Meng A., Feng X.H.Cell 125:915-928(2006)
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.He W., Dorn D.C., Erdjument-Bromage H., Tempst P., Moore M.A., Massague J.Cell 125:929-941(2006)
The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.Simonsson M., Kanduri M., Gronroos E., Heldin C.H., Ericsson J.J. Biol. Chem. 281:39870-39880(2006)
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.Sun Y., Ding L., Zhang H., Han J., Yang X., Yan J., Zhu Y., Li J., Song H., Ye Q.Nucleic Acids Res. 34:6314-6326(2006)
3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.Seong H.A., Jung H., Kim K.T., Ha H.J. Biol. Chem. 282:12272-12289(2007)
Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.Arndt S., Poser I., Moser M., Bosserhoff A.-K.Mol. Cell. Neurosci. 34:603-611(2007)
Smad3 is acetylated by p300/CBP to regulate its transactivation activity.Inoue Y., Itoh Y., Abe K., Okamoto T., Daitoku H., Fukamizu A., Onozaki K., Hayashi H.Oncogene 26:500-508(2007)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.Mol. Cell 31:438-448(2008)
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.Varelas X., Sakuma R., Samavarchi-Tehrani P., Peerani R., Rao B.M., Dembowy J., Yaffe M.B., Zandstra P.W., Wrana J.L.Nat. Cell Biol. 10:837-848(2008)
A quantitative atlas of mitotic phosphorylation.Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009)
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.Dai F., Lin X., Chang C., Feng X.H.Dev. Cell 16:345-357(2009)
SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.Takahata M., Inoue Y., Tsuda H., Imoto I., Koinuma D., Hayashi M., Ichikura T., Yamori T., Nagasaki K., Yoshida M., Matsuoka M., Morishita K., Yuki K., Hanyu A., Miyazawa K., Inazawa J., Miyazono K., Imamura T.J. Biol. Chem. 284:3334-3344(2009)
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.Watanabe Y., Itoh S., Goto T., Ohnishi E., Inamitsu M., Itoh F., Satoh K., Wiercinska E., Yang W., Shi L., Tanaka A., Nakano N., Mommaas A.M., Shibuya H., Ten Dijke P., Kato M.Mol. Cell 37:123-134(2010)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.Sci. Signal. 3:RA3-RA3(2010)
Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2.Luo Y., Hu W., Xu R., Hou B., Zhang L., Zhang W.Cell Biol. Int. 35:1153-1157(2011)
USP15 is a deubiquitylating enzyme for receptor-activated SMADs.Inui M., Manfrin A., Mamidi A., Martello G., Morsut L., Soligo S., Enzo E., Moro S., Polo S., Dupont S., Cordenonsi M., Piccolo S.Nat. Cell Biol. 13:1368-1375(2011)
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway.Bruce D.L., Macartney T., Yong W., Shou W., Sapkota G.P.Cell. Signal. 24:1999-2006(2012)
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012)
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012)
CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.Abbas T., Mueller A.C., Shibata E., Keaton M., Rossi M., Dutta A.Mol. Cell 49:1147-1158(2013)
C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.Nakano N., Maeyama K., Sakata N., Itoh F., Akatsu R., Nakata M., Katsu Y., Ikeno S., Togawa Y., Vo Nguyen T.T., Watanabe Y., Kato M., Itoh S.J. Biol. Chem. 289:12680-12692(2014)
TGF-beta signal transduction.Massague J.Annu. Rev. Biochem. 67:753-791(1998)
Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.Verschueren K., Huylebroeck D.Cytokine Growth Factor Rev. 10:187-199(1999)
The Smad pathway.Wrana J.L., Attisano L.Cytokine Growth Factor Rev. 11:5-13(2000)
TGF-beta signaling by Smad proteins.Miyazono K.Cytokine Growth Factor Rev. 11:15-22(2000)
Structural basis of Smad2 recognition by the Smad anchor for receptor activation.Wu G., Chen Y.-G., Ozdamar B., Gyuricza C.A., Chong P.A., Wrana J.L., Massague J., Shi Y.Science 287:92-97(2000)
Structural basis of heteromeric smad protein assembly in TGF-beta signaling.Chacko B.M., Qin B.Y., Tiwari A., Shi G., Lam S., Hayward L.J., De Caestecker M., Lin K.Mol. Cell 15:813-823(2004)
The consensus coding sequences of human breast and colorectal cancers.Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.Science 314:268-274(2006)
+Additional computationally mapped references.<p>Provides general information on the entry.
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