Dynein Light Chain 1 (DYNLL1) Antibody – Rabbit Polyclonal

Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

LC8: a highly conserved cytoplasmic protein of the dynein light chain family. Cytoplasmic dyneins are large enzyme complexes. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain. Interacts with and inhibits the activity of neuronal nitric oxide synthase (nNOS). A highly conserved protein, showing 92% amino acid similarity with the nematode homolog. Binding of this protein destabilizes the nNOS dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.

Protein type: Motor; Microtubule-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q24.23

Cellular Component: centrosome; cytoplasm; cytoplasmic dynein complex; cytosol; kinetochore; membrane; microtubule; mitochondrion; nucleus; plasma membrane; signalosome

Molecular Function: enzyme binding; motor activity; nitric-oxide synthase regulator activity; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity

Biological Process: actin cytoskeleton organization and biogenesis; anatomical structure morphogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; apoptosis; cellular protein metabolic process; ER to Golgi vesicle-mediated transport; female gamete generation; G2/M transition of mitotic cell cycle; macroautophagy; mitotic cell cycle; negative regulation of phosphorylation; organelle organization and biogenesis; post-translational protein modification; programmed cell death; protein amino acid N-linked glycosylation via asparagine; regulation of catalytic activity; regulation of transcription, DNA-dependent; substantia nigra development; transcription, DNA-dependent; viral reproduction