Substance-P Receptor (SPR) Antibody – Rabbit Polyclonal

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

TACR1: This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: cell surface; cytosol; dendrite; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; substance P receptor activity; tachykinin receptor activity

Biological Process: acute inflammatory response; angiotensin mediated drinking behavior; associative learning; behavioral response to pain; cell surface receptor linked signal transduction; detection of abiotic stimulus; eating behavior; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); inflammatory response; long-term memory; operant conditioning; positive regulation of action potential; positive regulation of blood pressure; positive regulation of epithelial cell proliferation; positive regulation of hormone secretion; positive regulation of leukocyte migration; positive regulation of lymphocyte proliferation; positive regulation of ossification; positive regulation of saliva secretion; positive regulation of smooth muscle contraction; positive regulation of stress fiber formation; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; positive regulation of vascular permeability; positive regulation of vasoconstriction; regulation of smooth muscle cell migration; regulation of smooth muscle cell proliferation; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to heat; response to morphine; response to nicotine; response to ozone; response to progesterone stimulus; smooth muscle contraction involved in micturition; sperm ejaculation; tachykinin signaling pathway