Vesicle-Fusing Atpase (NSF) Antibody – Rabbit Polyclonal

NSF: required for intracellular membrane fusion and vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Functions as a SNAP receptor (SNARE) chaperone which binds, through soluble NSF attachment proteins (SNAPs), to SNARE complexes and utilizes the energy of ATP hydrolysis to disassemble them thus facilitating SNARE recycling. While this is a major function of NSF, it does seem to interact with other proteins, such as the AMPA receptor subunit, GluR2, and beta2-AR and is thought to affect their trafficking patterns.

Protein type: Protease; EC 3.6.4.6; Autophagy; Adaptor/scaffold; Vesicle

Cellular Component: cytoplasm; dendritic shaft; Golgi stack; lysosomal membrane; myelin sheath; plasma membrane; postsynaptic density

Molecular Function: ATP binding; ATP-dependent protein binding; ATPase activity; ATPase activity, coupled; D1 dopamine receptor binding; metal ion binding; PDZ domain binding; protein binding; protein C-terminus binding; protein complex binding; protein kinase binding; Rab GTPase binding; syntaxin binding; syntaxin-1 binding

Biological Process: Golgi to plasma membrane protein transport; Golgi vesicle docking; intra-Golgi vesicle-mediated transport; intracellular protein transport; neurotransmitter secretion; positive regulation of protein catabolic process; positive regulation of receptor recycling; potassium ion transport; protein transport; regulation of exocytosis; vesicle fusion; vesicle-mediated transport