Gtpase Kras (KRAS) Antibody – Rabbit Polyclonal

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Ras; G protein; Oncoprotein; G protein, monomeric

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; lipid raft; membrane; mitochondrion; plasma membrane

Molecular Function: GDP binding; GMP binding; GTP binding; LRR domain binding; protein binding; protein complex binding

Biological Process: actin cytoskeleton organization and biogenesis; activation of MAPKK activity; activation of NF-kappaB transcription factor; axon guidance; blood coagulation; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; forebrain astrocyte development; homeostasis of number of cells within a tissue; innate immune response; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; negative regulation of cell differentiation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; small GTPase mediated signal transduction; social behavior; stimulatory C-type lectin receptor signaling pathway; striated muscle cell differentiation; vascular endothelial growth factor receptor signaling pathway; visual learning

Disease: Bladder Cancer; Breast Cancer; Cardiofaciocutaneous Syndrome 2; Gastric Cancer, Hereditary Diffuse; Leukemia, Acute Myeloid; Lung Cancer; Noonan Syndrome 3; Pancreatic Cancer; Schimmelpenning-feuerstein-mims Syndrome