Inhibitor of Kb Kinase Beta (IKKbeta) ELISA Kit for Human

IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer.

Protein type: EC 2.7.11.10; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family

Cellular Component: internal side of plasma membrane; membrane; intracellular membrane-bound organelle; cytoplasm; IkappaB kinase complex; cytosol; nucleus

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: serine phosphorylation of STAT protein; B cell homeostasis; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; phosphorylation; protein amino acid phosphorylation; neurite development; activation of NF-kappaB transcription factor