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CX3C-Chemokine/Fractalkine (FKN) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS731243

MBS731243 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the CX3C-chemokine/Fractalkine (FKN) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$580 / 48-Strip-Wells-(Competitive) +1 FREE 8GB USB

Product Documentation

PDF
Sample Competitive Manual Insert View PDF
PDF
Sample Sandwich Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CX3C-chemokine/Fractalkine (FKN), ELISA Kit
Full Product Name
Human CX3C-chemokine/Fractalkine ELISA Kit
Product Gene Name
FKN elisa kit
Species Reactivity
Human
Assay Type
Competitive or Sandwich
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C
Molecular Weight
42,203 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (57406414..57418956). Location: 16q13
OMIM
601880
3D Structure
ModBase 3D Structure for P78423
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Highest Standards
2000 pg/mL
Concentration of Standards
Concentration of Standards||0,100,250,500,1000,2500 pg/mL

Product Categories/Family for FKN elisa kit

Immunology
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of FKN elisa kit

Human FKN ELISA Kit – Cat# MBS731243

Other Notes

Small volumes of FKN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FKN. It may not necessarily be applicable to this product.

NCBI GI #
4506857
NCBI GeneID
6376
NCBI Accession #
NP_002987
UniProt Primary Accession #
P78423
UniProt Secondary Accession #
O00672
UniProt Related Accession #
P78423
GenBank Nucleotide #
NM_002996.3
NCBI Official Full Name
fractalkine
NCBI Official Synonym Full Names
chemokine (C-X3-C motif) ligand 1
NCBI Official Symbol
CX3CL1
NCBI Official Synonym Symbols
NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin
UniProt Protein Name
Fractalkine
UniProt Synonym Protein Names
C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1
UniProt Gene Name
CX3CL1
UniProt Synonym Gene Names
FKN; NTT; SCYD1
UniProt Entry Name
X3CL1_HUMAN
NCBI Protein Information
fractalkine; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)

UniProt Comments for FKN

CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; cell surface; extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding; chemokine activity; receptor binding

Biological Process: positive regulation of transforming growth factor-beta1 production; neutrophil chemotaxis; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; defense response; chemotaxis; angiogenesis involved in wound healing; leukocyte adhesive activation; macrophage chemotaxis; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of inflammatory response
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Research Articles on FKN

1. Fractalkine and its receptor CX3CR1 are expressed in the human brain after traumatic brain injury and intracranial hemorrhage and may be involved in the limitation of tissue damage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKN elisa kit

 Reference Product  PubMed Publications
 CX3CR1 elisa kit  >389 publications with FKN and CX3CR1
 CCR2 elisa kit  >46 publications with FKN and CCR2
 CXCR4 elisa kit  >31 publications with FKN and CXCR4
 CCR5 elisa kit  >31 publications with FKN and CCR5
 CXCR3 elisa kit  >22 publications with FKN and CXCR3
 CCR1 elisa kit  >17 publications with FKN and CCR1
 CCR3 elisa kit  >11 publications with FKN and CCR3
 CXCR6 elisa kit  >9 publications with FKN and CXCR6

Pathways associated with FKN elisa kit

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with FKN elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >264 publications with FKN and Inflammation
 Necrosis Antibodies  >151 publications with FKN and Necrosis
 Cardiovascular Diseases Antibodies  >119 publications with FKN and Cardiovascular Diseases
 Brain Diseases Antibodies  >77 publications with FKN and Brain Diseases
 Atherosclerosis Antibodies  >71 publications with FKN and Atherosclerosis
 Kidney Diseases Antibodies  >44 publications with FKN and Kidney Diseases
 Pain Antibodies  >43 publications with FKN and Pain
 Heart Diseases Antibodies  >38 publications with FKN and Heart Diseases
 Liver Diseases Antibodies  >35 publications with FKN and Liver Diseases
 Myocardial Ischemia Antibodies  >34 publications with FKN and Myocardial Ischemia

Organs/Tissues associated with FKN elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >143 publications with FKN and Brain
 Lung Antibodies  >74 publications with FKN and Lung
 Kidney Antibodies  >70 publications with FKN and Kidney
 Muscle Antibodies  >69 publications with FKN and Muscle
 Liver Antibodies  >51 publications with FKN and Liver
 Heart Antibodies  >49 publications with FKN and Heart
 Nerve Antibodies  >39 publications with FKN and Nerve
 Skin Antibodies  >34 publications with FKN and Skin
 Intestine Antibodies  >29 publications with FKN and Intestine
 Eye Antibodies  >21 publications with FKN and Eye
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