Anti-Neuronal Nuclear Autoantibody 1 (ANNA1) ELISA Kit for Mouse

ANXA1: a calcium/phospholipid-binding protein with which promotes membrane fusion and is involved in endocytosis. Has anti-inflammatory properties and inhibits phospholipase A2 activity. Accumulates on internalized vesicles after EGF-stimulated endocytosis, suggesting that it may be required for a late stage in inward vesiculation. Phosphorylated by PKC, EGFR and Chak1. Phosphorylation results in loss of the inhibitory activity. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Lipid-binding; Calcium-binding

Cellular Component: extracellular space; mast cell granule; cell surface; focal adhesion; protein complex; basolateral plasma membrane; cornified envelope; cilium; cytoplasm; mitochondrial membrane; plasma membrane; nucleus; vesicle; endosome; sarcolemma

Molecular Function: protein binding, bridging; protein homodimerization activity; single-stranded RNA binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; double-stranded DNA-dependent ATPase activity; phospholipid binding; calcium ion binding; structural molecule activity; helicase activity; calcium-dependent protein binding; single-stranded DNA binding

Biological Process: prostate gland development; response to peptide hormone stimulus; positive regulation of apoptosis; response to glucocorticoid stimulus; response to hormone stimulus; positive regulation of vesicle fusion; alpha-beta T cell differentiation; signal transduction; response to organic cyclic substance; response to estradiol stimulus; response to corticosteroid stimulus; cell surface receptor linked signal transduction; positive regulation of prostaglandin biosynthetic process; response to X-ray; response to drug; negative regulation of protein secretion; positive regulation of neutrophil apoptosis; gliogenesis; arachidonic acid secretion; neutrophil homeostasis; endocrine pancreas development; DNA duplex unwinding; regulation of cell proliferation; keratinocyte differentiation; insulin secretion; DNA strand renaturation; peptide cross-linking