AQP1: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family
Cellular Component: neuron projection; nuclear membrane; cell; integral to plasma membrane; basolateral plasma membrane; brush border membrane; integral to membrane; membrane; apical part of cell; axon; cytoplasm; apical plasma membrane; plasma membrane; basal plasma membrane; nerve terminal; nucleus; sarcolemma; brush border
Molecular Function: protein binding; ephrin receptor binding; potassium channel activity; water transporter activity; ammonium transmembrane transporter activity; intracellular cGMP activated cation channel activity; potassium ion transmembrane transporter activity; glycerol transmembrane transporter activity; transmembrane transporter activity; nitric oxide transporter activity; water channel activity; glycerol channel activity
Biological Process: cGMP biosynthetic process; glycerol transport; cerebrospinal fluid secretion; wound healing; water transport; carbon dioxide transport; response to hormone stimulus; negative regulation of caspase activity; pancreatic juice secretion; sensory perception of pain; positive regulation of saliva secretion; water homeostasis; odontogenesis; positive regulation of fibroblast proliferation; hyperosmotic salinity response; nitric oxide transport; multicellular organismal water homeostasis; cellular homeostasis; lateral ventricle development; potassium ion transport; lipid digestion; secretion by cell; response to drug; cellular water homeostasis; secretory granule organization and biogenesis; glomerular filtration; ammonium transport; positive regulation of angiogenesis; renal water transport; hyperosmotic response; camera-type eye morphogenesis; response to estrogen stimulus; adrenocorticotropin hormone secretion; establishment and/or maintenance of actin cytoskeleton polarity; cell volume homeostasis; positive regulation of cell migration; negative regulation of apoptosis
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