Dynamin 2 (DNM2) ELISA Kit for Human

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

DYN2: a cytoplasmic microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. May mediate the conventional clathrin-mediated uptake of surface receptors. Expressed in the postsynaptic density of neuronal cells. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Vesicle; Hydrolase; Microtubule-binding; EC 3.6.5.5

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: Golgi membrane; Golgi apparatus; microtubule; postsynaptic membrane; focal adhesion; growth cone; postsynaptic density; cytoplasm; plasma membrane; coated pit; midbody; cytosol

Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; microtubule binding; SH3 domain binding

Biological Process: receptor-mediated endocytosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; synaptic vesicle transport; transferrin transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; endocytosis; regulation of axon extension; signal transduction; nitric oxide metabolic process; regulation of transcription, DNA-dependent; receptor internalization; regulation of nitric-oxide synthase activity; post-Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; neurite morphogenesis

Disease: Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1; Charcot-marie-tooth Disease, Dominant Intermediate B