Chicken CASP4 ELISA Kit – Cat# MBS734869

Caspase 4-Apoptosis-Related Cysteine Peptidase (CASP4) ELISA Kit for Chicken

Name: Chicken CASP4 ELISA Kit; Caspase 4-Apoptosis-Related Cysteine Peptidase; MyBioSource
Brand: MyBioSource
SKU: MBS734869
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS734869

MBS734869 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Caspase 4-apoptosis-related cysteine peptidase (Casp4) ELISA Kit target analytes in biological samples. The concentration… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Caspase 4-apoptosis-related cysteine peptidase (Casp4), ELISA Kit

Full Product Name

Chicken Caspase 4-apoptosis-related cysteine peptidase ELISA Kit

Product Gene Name

Casp4 elisa kit

Species Reactivity

Chicken

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Preparation and Storage

Store all reagents at 2-8 degree C.

Molecular Weight

36,705 Da

OMIM

602664

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Product Categories/Family for Casp4 elisa kit

Immunology

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of Casp4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Casp4. It may not necessarily be applicable to this product.

NCBI GI #

119587455

NCBI GeneID

837

NCBI Accession #

EAW67051.1

UniProt Secondary Accession #

A2NHL8; A2NHM0

UniProt Related Accession #

P49662

NCBI Official Full Name

caspase 4, apoptosis-related cysteine peptidase, isoform CRA_b

NCBI Official Synonym Full Names

caspase 4, apoptosis-related cysteine peptidase

NCBI Official Symbol

CASP4

NCBI Official Synonym Symbols

TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

UniProt Protein Name

Caspase-4

UniProt Synonym Protein Names

ICE(rel)-II; Protease ICH-2; Protease TXCleaved into the following 2 chains:Caspase-4 subunit 1; Caspase-4 subunit 2

Protein Family

Caspase

UniProt Gene Name

CASP4

UniProt Synonym Gene Names

ICH2; CASP-4

UniProt Entry Name

CASP4_HUMAN

NCBI Protein Information

caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease

NCBI Summary for Casp4

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for Casp4

CASP4: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.64; Protease

Chromosomal Location of Human Ortholog: 11q22.2-q22.3

Cellular Component: endoplasmic reticulum membrane; mitochondrion; cytoplasm

Molecular Function: cysteine-type endopeptidase activity

Biological Process: regulation of apoptosis; apoptosis; regulation of inflammatory response; proteolysis

Research Articles on Casp4

1. caspase-4 can support activation of caspase-1 and secretion of IL-1beta and IL-18 in response to priming signals (LPS or Pam3CSK4) alon

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Casp4 elisa kit

Reference Product	PubMed Publications
CASP1 elisa kit	>32 publications with Casp4 and CASP1
CASP8 elisa kit	>17 publications with Casp4 and CASP8
IL18 elisa kit	>6 publications with Casp4 and IL18
PSEN1 elisa kit	>2 publications with Casp4 and PSEN1
APAF1 elisa kit	>2 publications with Casp4 and APAF1
TRAF6 elisa kit	>2 publications with Casp4 and TRAF6
SERPINB9 elisa kit	>1 publications with Casp4 and SERPINB9
IL1B elisa kit	>1 publications with Casp4 and IL1B
NOD1 elisa kit	>1 publications with Casp4 and NOD1

Pathways associated with Casp4 elisa kit

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Caspase Cascade In Apoptosis Pathway antibodies	Caspase Cascade In Apoptosis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
NOD1/2 Signaling Pathway antibodies	NOD1/2 Signaling Pathway Diagram
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram

Diseases associated with Casp4 elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>14 publications with Casp4 and Inflammation
Necrosis Antibodies	>12 publications with Casp4 and Necrosis
Gastrointestinal Diseases Antibodies	>11 publications with Casp4 and Gastrointestinal Diseases
Carcinoma, Squamous Cell Antibodies	>7 publications with Casp4 and Carcinoma, Squamous Cell
Breast Neoplasms Antibodies	>7 publications with Casp4 and Breast Neoplasms
Liver Diseases Antibodies	>6 publications with Casp4 and Liver Diseases
Lung Diseases Antibodies	>5 publications with Casp4 and Lung Diseases
Cardiovascular Diseases Antibodies	>5 publications with Casp4 and Cardiovascular Diseases
Lung Neoplasms Antibodies	>5 publications with Casp4 and Lung Neoplasms
Nervous System Diseases Antibodies	>5 publications with Casp4 and Nervous System Diseases

Organs/Tissues associated with Casp4 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with Casp4 and Blood
Lung Antibodies	>10 publications with Casp4 and Lung
Liver Antibodies	>9 publications with Casp4 and Liver
Mouth Antibodies	>4 publications with Casp4 and Mouth
Brain Antibodies	>4 publications with Casp4 and Brain
Vascular Antibodies	>3 publications with Casp4 and Vascular
Pancreas Antibodies	>3 publications with Casp4 and Pancreas
Kidney Antibodies	>3 publications with Casp4 and Kidney
Heart Antibodies	>3 publications with Casp4 and Heart
Eye Antibodies	>3 publications with Casp4 and Eye