Aryl Hydrocarbon Receptor (AhR) ELISA Kit for Porcine

AHR: a nuclear receptor for aryl hydrocarbons involved in xenobiotic metabolism, cell cycle regulation, and development in response to both endogenous and environmental signals. AhR was initially identified as a receptor for dioxins, which are environmental pollutants generated by waste incineration and other industrial processes . AhR ligands include polycyclic aromatic hydrocarbons, including the carcinogen benzo(a)pyrene and other components of cigarette smoke. Naturally occurring AhR ligands include flavonoids, which are aromatic plant secondary compounds commonly found in vegetables and fruits. Cytoplasmic aryl hydrocarbon receptors are found in protein complexes with heat shock proteins. Upon ligand binding, AhR dissociates from heat shock proteins and translocate to the nucleus where it dimerizes with AhR nuclear translocator (ARNT, HIF-1b). The AhR/ARNT heterodimer binds to nuclear xenobiotic response elements to control the expression of genes associated with xenobiotic metabolism, including several cytochrome P450 genes. AhR is ubiquitously expressed and is thought to play a role in regulation of cell proliferation and differentiation, cytokine expression, and xenobiotic metabolism. Research studies link AhR activity with the control of regulatory T-cell and T-helper 17 cell differentiation, regulation of the inflammatory response, and the onset of lung cancer.

Protein type: Nuclear receptor; Transcription factor; DNA-binding

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus

Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; signal transducer activity; protein binding; ligand-dependent nuclear receptor activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; aryl hydrocarbon receptor activity; Hsp90 protein binding; transcription factor binding; transcription factor activity

Biological Process: prostate gland development; transcription from RNA polymerase II promoter; gland development; positive regulation of cell size; blood circulation; positive regulation of transcription, DNA-dependent; response to toxin; rhythmic process; cell morphogenesis; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to organic cyclic substance; smooth muscle development; ovarian follicle development; B cell homeostasis; regulation of transcription, DNA-dependent; post-embryonic hemopoiesis; regulation of blood pressure; response to stress; T cell homeostasis; regulation of B cell proliferation; circadian regulation of gene expression; regulation of blood vessel size; positive regulation of transcriptional preinitiation complex assembly; positive regulation of growth; spleen development; blood vessel development; intracellular receptor-mediated signaling pathway; camera-type eye development; transcription, DNA-dependent; embryonic hemopoiesis; immune system process; negative regulation of systemic arterial blood pressure; B-1 B cell homeostasis; cell cycle; liver development; negative regulation of vasoconstriction; patterning of blood vessels; regulation of transcription from RNA polymerase II promoter; response to xenobiotic stimulus; regulation of gene expression; B cell differentiation; xenobiotic metabolic process; blood vessel morphogenesis; blood vessel remodeling; negative regulation of transcription, DNA-dependent; reproductive structure development; lymphocyte homeostasis