Ryanodine Receptor 2, Cardiac (RYR2) ELISA Kit for Goose

Name: Goose RYR2 ELISA Kit; Ryanodine Receptor 2, Cardiac; MyBioSource
Brand: MyBioSource
SKU: MBS073892
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS073892

MBS073892 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ryanodine Receptor 2, Cardiac (RYR2) ELISA Kit target analytes in biological samples. The concentration gradients of the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Ryanodine Receptor 2, Cardiac (RYR2), ELISA Kit

Full Product Name

Goose Ryanodine Receptor 2, Cardiac ELISA Kit

Product Gene Name

RYR2 elisa kit

Species Reactivity

Goose

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

564,567 Da

OMIM

180902

3D Structure

ModBase 3D Structure for Q92736

Other Notes

Small volumes of RYR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RYR2. It may not necessarily be applicable to this product.

NCBI GI #

112799847

NCBI GeneID

6262

NCBI Accession #

NP_001026.2

UniProt Primary Accession #

Q92736

UniProt Secondary Accession #

Q15411; Q546N8; Q5T3P2

UniProt Related Accession #

Q92736

GenBank Nucleotide #

NM_001035.2

NCBI Official Full Name

ryanodine receptor 2

NCBI Official Synonym Full Names

ryanodine receptor 2 (cardiac)

NCBI Official Symbol

RYR2

NCBI Official Synonym Symbols

RyR; ARVC2; ARVD2; RYR-2; VTSIP

UniProt Protein Name

Ryanodine receptor 2

UniProt Synonym Protein Names

Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor

Protein Family

Ryanodine receptor

UniProt Gene Name

RYR2

UniProt Synonym Gene Names

RYR-2; RyR2; hRYR-2

UniProt Entry Name

RYR2_HUMAN

NCBI Protein Information

ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel

NCBI Summary for RYR2

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

UniProt Comments for RYR2

RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described.

Protein type: Transporter, ion channel; Membrane protein, integral; Transporter; Membrane protein, multi-pass; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: sarcoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; membrane; sarcoplasmic reticulum; plasma membrane; Z disc

Molecular Function: calmodulin binding; calcium-induced calcium release activity; identical protein binding; protein binding; enzyme binding; protein self-association; calcium channel activity; calcium-release channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity

Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; response to redox state; positive regulation of heart rate; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; cellular calcium ion homeostasis; BMP signaling pathway; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction

Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2

Research Articles on RYR2

1. CPVT is an inherited cardiac disorder in which patients have structurally normal hearts but increased risk of stress-induced ventricular arrhythmias because of mutations in the cardiac "ryanodine receptor 2" (RyR2; CPVT1)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RYR2 elisa kit

Reference Product	PubMed Publications
TRDN elisa kit	>45 publications with RYR2 and TRDN
CACNA1S elisa kit	>24 publications with RYR2 and CACNA1S
NOS1 elisa kit	>13 publications with RYR2 and NOS1
CACNA1C elisa kit	>6 publications with RYR2 and CACNA1C
AKAP6 elisa kit	>6 publications with RYR2 and AKAP6
FKBP1B elisa kit	>5 publications with RYR2 and FKBP1B
PKD2L1 elisa kit	>1 publications with RYR2 and PKD2L1

Pathways associated with RYR2 elisa kit

Products by Pathway	Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies	Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram

Diseases associated with RYR2 elisa kit

Disease Name	Pubmed Publications
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY Antibodies	>18365 publications with RYR2 and VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1, WITH OR WITHOUT ATRIAL DYSFUNCTION AND/OR DILATED CARDIOMYOPATHY
Heart Diseases Antibodies	>946 publications with RYR2 and Heart Diseases
Arrhythmias, Cardiac Antibodies	>552 publications with RYR2 and Arrhythmias, Cardiac
Nervous System Diseases Antibodies	>445 publications with RYR2 and Nervous System Diseases
Heart Failure Antibodies	>436 publications with RYR2 and Heart Failure
Tachycardia Antibodies	>345 publications with RYR2 and Tachycardia
Tachycardia, Ventricular Antibodies	>328 publications with RYR2 and Tachycardia, Ventricular
Disease Models, Animal Antibodies	>230 publications with RYR2 and Disease Models, Animal
Cardiomyopathies Antibodies	>150 publications with RYR2 and Cardiomyopathies
Cardiomegaly Antibodies	>109 publications with RYR2 and Cardiomegaly