Heparin Cofactor II (HC II) ELISA Kit for Sheep

Name: Sheep HC II ELISA Kit; Heparin Cofactor II; MyBioSource
Brand: MyBioSource
SKU: MBS739832
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS739832

MBS739832 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Heparin Cofactor II (HC II) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Heparin Cofactor II (HC II), ELISA Kit

Full Product Name

Sheep Heparin Cofactor II ELISA Kit

Product Gene Name

HC II elisa kit

Species Reactivity

Sheep

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Preparation and Storage

Store all reagents at 2-8 degree C.

Molecular Weight

57,071 Da

OMIM

gene 612356

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Product Categories/Family for HC II elisa kit

Cardiovascular

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of HC II elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HC II. It may not necessarily be applicable to this product.

NCBI GI #

73858566

NCBI GeneID

3053

NCBI Accession #

NP_000176.2

UniProt Secondary Accession #

Q6IBZ5; B2RAI1; D3DX34

UniProt Related Accession #

P05546

GenBank Nucleotide #

NM_000185.3

NCBI Official Full Name

heparin cofactor 2

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

NCBI Official Symbol

SERPIND1

NCBI Official Synonym Symbols

HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673

UniProt Protein Name

Heparin cofactor 2

UniProt Synonym Protein Names

Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1

Protein Family

Heparin cofactor

UniProt Gene Name

SERPIND1

UniProt Synonym Gene Names

HCF2; HC-II; HLS2

UniProt Entry Name

HEP2_HUMAN

NCBI Protein Information

heparin cofactor 2; serpin D1; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

NCBI Summary for HC II

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008]

UniProt Comments for HC II

SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; endopeptidase inhibitor activity

Biological Process: chemotaxis; blood coagulation

Disease: Heparin Cofactor Ii Deficiency

Research Articles on HC II

1. In this study, we demonstrate a previously unknown role for HCII in host defense.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HC II elisa kit

Reference Product	PubMed Publications
SERPINC1 elisa kit	>3 publications with HC II and SERPINC1

Pathways associated with HC II elisa kit

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram

Diseases associated with HC II elisa kit

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>1 publications with HC II and Heart Diseases
Liver Diseases Antibodies	>1 publications with HC II and Liver Diseases
Hyperplasia Antibodies	>1 publications with HC II and Hyperplasia
Necrosis Antibodies	>1 publications with HC II and Necrosis
Heparin Cofactor II Deficiency Antibodies	>1 publications with HC II and Heparin Cofactor II Deficiency

Organs/Tissues associated with HC II elisa kit

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>5 publications with HC II and Liver
Vascular Antibodies	>3 publications with HC II and Vascular
Kidney Antibodies	>1 publications with HC II and Kidney
Lung Antibodies	>1 publications with HC II and Lung