Filamin B, Beta (FLNB) ELISA Kit for Chicken

Name: Chicken FLNB ELISA Kit; Filamin B, Beta; MyBioSource
Brand: MyBioSource
SKU: MBS740299
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS740299

Principle of the Assay: FLNB ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-FLNB antibody and an FLNB-HRP conjugate. The assay sample and buffer are incubated together with FLNB-HRP conjugate in pre-coated plate for… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Filamin B, Beta (FLNB), ELISA Kit

Full Product Name

Chicken Filamin B, Beta ELISA Kit

Product Gene Name

FLNB elisa kit

Species Reactivity

Chicken

Assay Type

Competitive

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Sensitivity

0.1 ng/mL.

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

278,164 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (57994127..58157982). Location: 3p14.3

OMIM

108720

3D Structure

ModBase 3D Structure for O75369

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Intended Uses

This FLNB ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Chicken FLNB. This ELISA kit for research use only, not for therapeutic applications!

Product Categories/Family for FLNB elisa kit

Signal Transduction

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of FLNB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FLNB purchase

MBS740299 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Filamin B, Beta (FLNB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLNB. The ELISA analytical biochemical technique of the MBS740299 kit is based on FLNB antibody-FLNB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLNB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLNB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FLNB. It may not necessarily be applicable to this product.

NCBI GI #

256222415

NCBI GeneID

2317

NCBI Accession #

NP_001157791.1

UniProt Primary Accession #

O75369

UniProt Secondary Accession #

Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4

UniProt Related Accession #

O75369; Q68CT4; Q8WXT3

GenBank Nucleotide #

NM_001164319.1

NCBI Official Full Name

filamin-B isoform 4

NCBI Official Synonym Full Names

filamin B, beta

NCBI Official Symbol

FLNB

NCBI Official Synonym Symbols

AOI; FH1; SCT; TAP; LRS1; TABP; FLN-B; FLN1L; ABP-278; ABP-280

UniProt Protein Name

Filamin-B

UniProt Synonym Protein Names

ABP-278; ABP-280 homolog; Actin-binding-like protein; Beta-filamin; Filamin homolog 1; Fh1; Filamin-3; Thyroid autoantigen; Truncated actin-binding protein

Protein Family

Filamin

UniProt Gene Name

FLNB

UniProt Synonym Gene Names

FLN1L; FLN3; TABP; TAP; FLN-B; Fh1

UniProt Entry Name

FLNB_HUMAN

NCBI Protein Information

filamin-B; filamin-3; beta-filamin; ABP-280 homolog; filamin homolog 1; thyroid autoantigen; actin binding protein 278; actin-binding-like protein; Larsen syndrome 1 (autosomal dominant)

NCBI Summary for FLNB

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

UniProt Comments for FLNB

FLNB: a ubiquitous cytoskeletal protein that links actin filaments to membrane glycoproteins. Six alternatively spliced isoforms have been described. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoforms 1 and 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells, retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord and platelets. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer's disease. Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 3p14.3

Cellular Component: focal adhesion; cytoplasm; integral to membrane; plasma membrane; stress fiber; cell cortex; cytosol; Z disc; actin cytoskeleton

Molecular Function: identical protein binding; protein binding; actin binding

Biological Process: skeletal muscle development; cytoskeletal anchoring; cytokine and chemokine mediated signaling pathway; cell differentiation; actin cytoskeleton organization and biogenesis; signal transduction

Disease: Larsen Syndrome; Boomerang Dysplasia; Atelosteogenesis, Type I; Spondylocarpotarsal Synostosis Syndrome; Atelosteogenesis, Type Iii

Research Articles on FLNB

1. these data demonstrate that coordinated expression of GPIbalpha and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FLNB elisa kit

Reference Product	PubMed Publications
FLNA elisa kit	>12 publications with FLNB and FLNA

Pathways associated with FLNB elisa kit

Products by Pathway	Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with FLNB elisa kit

Disease Name	Pubmed Publications
Craniofacial Abnormalities Antibodies	>7 publications with FLNB and Craniofacial Abnormalities
Spondylocarpotarsal synostosis Antibodies	>7 publications with FLNB and Spondylocarpotarsal synostosis
Boomerang dysplasia Antibodies	>6 publications with FLNB and Boomerang dysplasia
Nervous System Diseases Antibodies	>2 publications with FLNB and Nervous System Diseases
Cardiovascular Diseases Antibodies	>2 publications with FLNB and Cardiovascular Diseases
Movement Disorders Antibodies	>2 publications with FLNB and Movement Disorders
ATELOSTEOGENESIS, TYPE III Antibodies	>2 publications with FLNB and ATELOSTEOGENESIS, TYPE III
Disease Models, Animal Antibodies	>1 publications with FLNB and Disease Models, Animal
Brain Diseases Antibodies	>1 publications with FLNB and Brain Diseases
Neoplasms Antibodies	>1 publications with FLNB and Neoplasms

Organs/Tissues associated with FLNB elisa kit

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>13 publications with FLNB and Bone
Heart Antibodies	>4 publications with FLNB and Heart
Connective Tissue Antibodies	>4 publications with FLNB and Connective Tissue
Muscle Antibodies	>3 publications with FLNB and Muscle
Brain Antibodies	>3 publications with FLNB and Brain
Embryonic Tissue Antibodies	>2 publications with FLNB and Embryonic Tissue
Vascular Antibodies	>2 publications with FLNB and Vascular
Bone Marrow Antibodies	>1 publications with FLNB and Bone Marrow
Ear Antibodies	>1 publications with FLNB and Ear
Kidney Antibodies	>1 publications with FLNB and Kidney