Proteolipid Protein 1, Myelin (PLP1) ELISA Kit for Chicken

Name: Chicken PLP1 ELISA Kit; Proteolipid Protein 1, Myelin; MyBioSource
Brand: MyBioSource
SKU: MBS743841
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS743841

Intended Uses: This PLP1 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Chicken PLP1. This ELISA kit for research use only!Principle of the Assay: PLP1 ELISA kit applies the competitive enzyme immunoassay technique… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Proteolipid Protein 1, Myelin (PLP1), ELISA Kit

Full Product Name

Chicken Proteolipid Protein 1, Myelin ELISA Kit

Product Gene Name

PLP1 elisa kit

Species Reactivity

Chicken

Assay Type

Competitive

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Sensitivity

0.1 ng/mL.

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

30,077 Da

OMIM

300401

3D Structure

ModBase 3D Structure for P60201

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Product Categories/Family for PLP1 elisa kit

Neurobiology

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of PLP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLP1 purchase

MBS743841 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Proteolipid Protein 1, Myelin (PLP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PLP1. The ELISA analytical biochemical technique of the MBS743841 kit is based on PLP1 antibody-PLP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PLP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PLP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PLP1. It may not necessarily be applicable to this product.

NCBI GI #

49168568

NCBI Accession #

CAG38779.1

UniProt Primary Accession #

P60201

UniProt Secondary Accession #

P04400; P06905; Q502Y1; Q6FHZ6

NCBI Official Full Name

PLP1

UniProt Protein Name

Myelin proteolipid protein

UniProt Synonym Protein Names

Lipophilin

Protein Family

Patatin-like protein

UniProt Gene Name

PLP1

UniProt Synonym Gene Names

PLP; PLP

UniProt Entry Name

MYPR_HUMAN

NCBI Summary for PLP1

This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]

UniProt Comments for PLP1

PLP1: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1); also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay. Defects in PLP1 are the cause of spastic paraplegia X- linked type 2 (SPG2). SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. Belongs to the myelin proteolipid protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell surface

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: plasma membrane; integral to membrane; myelin sheath

Molecular Function: structural constituent of myelin sheath; structural molecule activity

Biological Process: integrin-mediated signaling pathway; synaptic transmission; substantia nigra development; myelination in the central nervous system; cell maturation; long-chain fatty acid biosynthetic process; axon ensheathment; inflammatory response; astrocyte development

Disease: Spastic Paraplegia 2, X-linked; Pelizaeus-merzbacher Disease

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLP1 elisa kit

Reference Product	PubMed Publications
FLNA elisa kit	>12 publications with PLP1 and FLNA

Pathways associated with PLP1 elisa kit

Products by Pathway	Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with PLP1 elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>160 publications with PLP1 and Nervous System Diseases
Pelizaeus-Merzbacher Disease Antibodies	>111 publications with PLP1 and Pelizaeus-Merzbacher Disease
Disease Models, Animal Antibodies	>66 publications with PLP1 and Disease Models, Animal
Nerve Degeneration Antibodies	>20 publications with PLP1 and Nerve Degeneration
Spastic paraplegia 2, X-linked Antibodies	>15 publications with PLP1 and Spastic paraplegia 2, X-linked
Ataxia Antibodies	>12 publications with PLP1 and Ataxia
Inflammation Antibodies	>10 publications with PLP1 and Inflammation
Congenital Abnormalities Antibodies	>10 publications with PLP1 and Congenital Abnormalities
Schizophrenia Antibodies	>10 publications with PLP1 and Schizophrenia
Nervous System Malformations Antibodies	>8 publications with PLP1 and Nervous System Malformations

Organs/Tissues associated with PLP1 elisa kit

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>161 publications with PLP1 and Nerve
Brain Antibodies	>130 publications with PLP1 and Brain
Blood Antibodies	>36 publications with PLP1 and Blood
Spinal Cord Antibodies	>33 publications with PLP1 and Spinal Cord
Embryonic Tissue Antibodies	>20 publications with PLP1 and Embryonic Tissue
Spleen Antibodies	>6 publications with PLP1 and Spleen
Skin Antibodies	>5 publications with PLP1 and Skin
Eye Antibodies	>4 publications with PLP1 and Eye
Ganglia Antibodies	>4 publications with PLP1 and Ganglia
Muscle Antibodies	>3 publications with PLP1 and Muscle