Interleukin 1beta Converting Enzyme (ICE) ELISA Kit for Chicken

Name: Chicken ICE ELISA Kit; Interleukin 1beta Converting Enzyme; MyBioSource
Brand: MyBioSource
SKU: MBS744084
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS744084

MBS744084 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin 1beta converting enzyme (ICE) ELISA Kit target analytes in biological samples. The concentration gradients of the… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 1beta converting enzyme (ICE), ELISA Kit

Full Product Name

Chicken Interleukin 1beta converting enzyme ELISA Kit

Product Gene Name

ICE elisa kit

Product Synonym Names

Chicken Interleukin 1b converting enzyme ELISA Kit

Species Reactivity

Chicken

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

45,331 Da

Chromosome Location

Chromosome: 7; NC_009150.2 (14609517..14619018, complement). Location: chromosome: 7

3D Structure

ModBase 3D Structure for Q9TV13

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Product Categories/Family for ICE elisa kit

Immunology

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of ICE elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ICE. It may not necessarily be applicable to this product.

NCBI GI #

126352357

NCBI GeneID

100033888

NCBI Accession #

NP_001075311.1

UniProt Primary Accession #

Q9TV13

UniProt Related Accession #

Q9TV13

GenBank Nucleotide #

NM_001081842.1

NCBI Official Full Name

caspase-1

NCBI Official Symbol

CASP1

UniProt Protein Name

Caspase-1

UniProt Synonym Protein Names

Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45

UniProt Gene Name

CASP1

UniProt Synonym Gene Names

IL1BC; CASP-1; IL-1BC; ICE

UniProt Entry Name

CASP1_HORSE

NCBI Protein Information

caspase-1; ICE; p45; CASP-1; IL-1BC; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

UniProt Comments for ICE

Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis

By similarity.

Catalytic activity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.

Subunit structure: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Interacts with CARD17/INCA and CARD18

By similarity.

Subcellular location: Cytoplasm.

Post-translational modification: The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Sequence similarities: Belongs to the peptidase C14A family.Contains 1 CARD domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with ICE elisa kit

Products by Pathway	Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Legionellosis Pathway antibodies	Legionellosis Pathway Diagram
Legionellosis Pathway antibodies	Legionellosis Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram
NOD-like Receptor Signaling Pathway antibodies	NOD-like Receptor Signaling Pathway Diagram

Diseases associated with ICE elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>786 publications with ICE and Inflammation
Necrosis Antibodies	>505 publications with ICE and Necrosis
Neoplasms Antibodies	>383 publications with ICE and Neoplasms
Nervous System Diseases Antibodies	>297 publications with ICE and Nervous System Diseases
Brain Diseases Antibodies	>229 publications with ICE and Brain Diseases
Cardiovascular Diseases Antibodies	>185 publications with ICE and Cardiovascular Diseases
Drug Toxicity Antibodies	>180 publications with ICE and Drug Toxicity
Gastrointestinal Diseases Antibodies	>114 publications with ICE and Gastrointestinal Diseases
Carcinoma Antibodies	>101 publications with ICE and Carcinoma
Sepsis Antibodies	>78 publications with ICE and Sepsis