Anti Beta 1 Adrenergic Receptor Antibodies (b1AR) ELISA Kit for Mouse

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: integral to plasma membrane; early endosome; plasma membrane; nucleus

Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; norepinephrine binding; drug binding; epinephrine binding; beta-adrenergic receptor activity; alpha-2A adrenergic receptor binding; Ras guanyl-nucleotide exchange factor activity; PDZ domain binding; beta1-adrenergic receptor activity

Biological Process: fear response; diet induced thermogenesis; glycogen catabolic process; negative regulation of multicellular organism growth; wound healing; positive regulation of apoptosis; apoptosis; adenylate cyclase activation; lipid homeostasis; positive regulation of systemic arterial blood pressure; regulation of calcium ion transport; sensory perception of pain; positive regulation of saliva secretion; memory; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; aging; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure

Disease: Resting Heart Rate, Variation In