Mouse ALPHA-2-MRAP ELISA Kit – Cat# MBS745150

Alpha-2-Macroglobulin Receptor-Associated (ALPHA-2-MRAP) ELISA Kit for Mouse

Name: Mouse ALPHA-2-MRAP ELISA Kit; Alpha-2-Macroglobulin Receptor-Associated; MyBioSource
Brand: MyBioSource
SKU: MBS745150
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS745150

MBS745150 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) ELISA Kit target analytes in biological samples. The… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP), ELISA Kit

Full Product Name

Mouse Alpha-2-macroglobulin receptor-associated protein ELISA Kit

Product Gene Name

Alpha-2-MRAP elisa kit

Species Reactivity

Mouse

Assay Type

Competitive

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Detection Range

2.5-50ng/mL

Sensitivity

0.1ng/mL

Preparation and Storage

Store all reagents at 2-8 degree C.

Molecular Weight

41,466 Da

OMIM

gene 615431

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Intended Uses

This LRPAP1 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Mouse LRPAP1. This ELISA kit for research use only, not for therapeutic applications!

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of Alpha-2-MRAP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Alpha-2-MRAP. It may not necessarily be applicable to this product.

NCBI GI #

4505021

NCBI GeneID

4043

NCBI Accession #

NP_002328.1

UniProt Secondary Accession #

Q2M310; Q53HQ3; Q53HS6; D3DVR9

UniProt Related Accession #

P30533

GenBank Nucleotide #

NM_002337.3

NCBI Official Full Name

alpha-2-macroglobulin receptor-associated protein

NCBI Official Synonym Full Names

low density lipoprotein receptor-related protein associated protein 1

NCBI Official Symbol

LRPAP1

NCBI Official Synonym Symbols

RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP

UniProt Protein Name

Alpha-2-macroglobulin receptor-associated protein

UniProt Synonym Protein Names

Low density lipoprotein receptor-related protein-associated protein 1; RAP

Protein Family

Alpha-2-macroglobulin receptor-associated protein

UniProt Gene Name

LRPAP1

UniProt Synonym Gene Names

A2MRAP; Alpha-2-MRAP; RAP

UniProt Entry Name

AMRP_HUMAN

NCBI Protein Information

alpha-2-macroglobulin receptor-associated protein; 39 kDa receptor-associated protein; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)

NCBI Summary for Alpha-2-MRAP

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

UniProt Comments for Alpha-2-MRAP

LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cell surface; endoplasmic reticulum; extracellular region; plasma membrane; integral to membrane; vesicle

Molecular Function: heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity

Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding

Disease: Myopia 23, Autosomal Recessive

Research Articles on Alpha-2-MRAP

1. RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Alpha-2-MRAP elisa kit

Reference Product	PubMed Publications
LRP1 elisa kit	>5 publications with Alpha-2-MRAP and LRP1
LRP2 elisa kit	>2 publications with Alpha-2-MRAP and LRP2
VLDLR elisa kit	>2 publications with Alpha-2-MRAP and VLDLR
LRP8 elisa kit	>1 publications with Alpha-2-MRAP and LRP8

Pathways associated with Alpha-2-MRAP elisa kit

Products by Pathway	Pathway Diagram
Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies	Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
Reelin Signaling Pathway antibodies	Reelin Signaling Pathway Diagram
Signaling Events Mediated By The Hedgehog Family Pathway antibodies	Signaling Events Mediated By The Hedgehog Family Pathway Diagram

Diseases associated with Alpha-2-MRAP elisa kit

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>6 publications with Alpha-2-MRAP and Brain Diseases
Atherosclerosis Antibodies	>3 publications with Alpha-2-MRAP and Atherosclerosis
Neurobehavioral Manifestations Antibodies	>2 publications with Alpha-2-MRAP and Neurobehavioral Manifestations
Chromosome Aberrations Antibodies	>1 publications with Alpha-2-MRAP and Chromosome Aberrations
Disease Models, Animal Antibodies	>1 publications with Alpha-2-MRAP and Disease Models, Animal
Cognition Disorders Antibodies	>1 publications with Alpha-2-MRAP and Cognition Disorders
Weight Loss Antibodies	>1 publications with Alpha-2-MRAP and Weight Loss
Prenatal Injuries Antibodies	>1 publications with Alpha-2-MRAP and Prenatal Injuries
Prenatal Exposure Delayed Effects Antibodies	>1 publications with Alpha-2-MRAP and Prenatal Exposure Delayed Effects

Organs/Tissues associated with Alpha-2-MRAP elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with Alpha-2-MRAP and Blood
Liver Antibodies	>4 publications with Alpha-2-MRAP and Liver
Brain Antibodies	>3 publications with Alpha-2-MRAP and Brain
Heart Antibodies	>2 publications with Alpha-2-MRAP and Heart
Kidney Antibodies	>2 publications with Alpha-2-MRAP and Kidney
Bone Antibodies	>2 publications with Alpha-2-MRAP and Bone
Vascular Antibodies	>2 publications with Alpha-2-MRAP and Vascular
Spleen Antibodies	>1 publications with Alpha-2-MRAP and Spleen
Bladder Antibodies	>1 publications with Alpha-2-MRAP and Bladder
Ovary Antibodies	>1 publications with Alpha-2-MRAP and Ovary