INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cell soma; extracellular region
Molecular Function: protein binding; growth factor activity; protein heterodimerization activity; hormone activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding
Biological Process: hemoglobin biosynthetic process; negative regulation of B cell differentiation; nervous system development; regulation of cell cycle; male gonad development; signal transduction; negative regulation of interferon-gamma biosynthetic process; regulation of cell proliferation; negative regulation of follicle-stimulating hormone secretion; negative regulation of cell cycle; regulation of apoptosis; response to external stimulus; cell surface receptor linked signal transduction; ovarian follicle development; negative regulation of macrophage differentiation; cell-cell signaling; regulation of MAPKKK cascade; erythrocyte differentiation; negative regulation of phosphorylation; positive regulation of follicle-stimulating hormone secretion; cell differentiation; cell cycle arrest; skeletal development; cell development
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