Scd163/Soluble Haemoglobin Scavenger Receptor (SCD163) ELISA Kit for Mouse

Name: Mouse SCD163 ELISA Kit; Scd163/Soluble Haemoglobin Scavenger Receptor; MyBioSource
Brand: MyBioSource
SKU: MBS007479
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS007479

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of SCD163 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

sCD163/Soluble Haemoglobin Scavenger Receptor, ELISA Kit

Full Product Name

Mouse sCD163/Soluble Haemoglobin Scavenger Receptor ELISA Kit

Product Gene Name

SCD163 elisa kit

Species Reactivity

Mouse

Assay Type

Sandwich (Quantitative)

Detection Range

62.5 ng/ml - 2000 ng/ml.

Sensitivity

10 ng/ml.

Specificity

No significant cross-reactivity or interference between this analyte and analogues is observed.

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

125,451 Da

OMIM

605545

3D Structure

ModBase 3D Structure for Q86VB7

Other Notes

Small volumes of SCD163 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCD163 purchase

MBS007479 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sCD163/Soluble Haemoglobin Scavenger Receptor, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SCD163. The ELISA analytical biochemical technique of the MBS007479 kit is based on SCD163 antibody-SCD163 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SCD163 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SCD163. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for SCD163. It may not necessarily be applicable to this product.

NCBI GI #

344179110

NCBI GeneID

9332

NCBI Accession #

NP_004235.4

UniProt Primary Accession #

Q86VB7

UniProt Secondary Accession #

Q07898; Q07899; Q07900; Q07901; Q2VLH7; C9JIG2

UniProt Related Accession #

Q86VB7

GenBank Nucleotide #

NM_004244.5

NCBI Official Full Name

scavenger receptor cysteine-rich type 1 protein M130 isoform a

NCBI Official Synonym Full Names

CD163 molecule

NCBI Official Symbol

CD163

NCBI Official Synonym Symbols

M130; MM130

UniProt Protein Name

Scavenger receptor cysteine-rich type 1 protein M130

UniProt Synonym Protein Names

Hemoglobin scavenger receptor

UniProt Gene Name

CD163

UniProt Synonym Gene Names

M130; sCD163

UniProt Entry Name

C163A_HUMAN

NCBI Protein Information

scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen

NCBI Summary for SCD163

The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

UniProt Comments for SCD163

CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; acute-phase response

Research Articles on SCD163

1. sCD163 correlates with CD163 mRNA expression in subcutaneous and visceral adipose tissue and with whole-body insulin sensitivity in the steady-state condition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCD163 elisa kit

Reference Product	PubMed Publications
CD68 elisa kit	>364 publications with SCD163 and CD68
IL10 elisa kit	>92 publications with SCD163 and IL10
HMOX1 elisa kit	>42 publications with SCD163 and HMOX1
CSF1R elisa kit	>28 publications with SCD163 and CSF1R
IL6 elisa kit	>11 publications with SCD163 and IL6
C1QB elisa kit	>1 publications with SCD163 and C1QB
VSIG4 elisa kit	>1 publications with SCD163 and VSIG4

Pathways associated with SCD163 elisa kit

Products by Pathway	Pathway Diagram
Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies	Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
Scavenging Of Heme From Plasma Pathway antibodies	Scavenging Of Heme From Plasma Pathway Diagram

Diseases associated with SCD163 elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>354 publications with SCD163 and Inflammation
Neoplasms Antibodies	>254 publications with SCD163 and Neoplasms
Necrosis Antibodies	>157 publications with SCD163 and Necrosis
Nervous System Diseases Antibodies	>102 publications with SCD163 and Nervous System Diseases
Brain Diseases Antibodies	>63 publications with SCD163 and Brain Diseases
Fibrosis Antibodies	>55 publications with SCD163 and Fibrosis
Lung Diseases Antibodies	>46 publications with SCD163 and Lung Diseases
Adenocarcinoma Antibodies	>39 publications with SCD163 and Adenocarcinoma
Heart Diseases Antibodies	>29 publications with SCD163 and Heart Diseases
Kidney Diseases Antibodies	>27 publications with SCD163 and Kidney Diseases

Organs/Tissues associated with SCD163 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>592 publications with SCD163 and Blood
Vascular Antibodies	>167 publications with SCD163 and Vascular
Skin Antibodies	>108 publications with SCD163 and Skin
Bone Antibodies	>100 publications with SCD163 and Bone
Liver Antibodies	>99 publications with SCD163 and Liver
Brain Antibodies	>70 publications with SCD163 and Brain
Lung Antibodies	>68 publications with SCD163 and Lung
Connective Tissue Antibodies	>46 publications with SCD163 and Connective Tissue
Heart Antibodies	>40 publications with SCD163 and Heart
Spleen Antibodies	>39 publications with SCD163 and Spleen