Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1) ELISA Kit for Chicken

RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described.

Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Rho

Cellular Component: extrinsic to plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; actin filament; trans-Golgi network; cytosol; Golgi membrane; cell projection; membrane; lamellipodium; cytoplasm; plasma membrane; cytoplasmic vesicle; intracellular; phagocytic cup

Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; GTP-dependent protein binding; histone deacetylase binding; thioesterase binding; Rho GDP-dissociation inhibitor binding; nucleotide binding; protein kinase binding; Rab GTPase binding

Biological Process: axon guidance; metabolic process; cell motility involved in cell locomotion; regulation of neuron maturation; chemotaxis; regulation of cell migration; localization within membrane; positive regulation of focal adhesion formation; actin filament polymerization; small GTPase mediated signal transduction; positive regulation of stress fiber formation; dendrite development; regulation of cell morphogenesis; cell adhesion; bone resorption; lamellipodium biogenesis; intercellular junction assembly and maintenance; embryonic olfactory bulb interneuron precursor migration; cell migration; mast cell chemotaxis; Wnt receptor signaling pathway, planar cell polarity pathway; dendrite morphogenesis; synaptic transmission, GABAergic; actin filament organization; positive regulation of phosphoinositide 3-kinase activity; cerebral cortex GABAergic interneuron development; cytoskeleton organization and biogenesis; endocytosis; engulfment of apoptotic cell; G-protein coupled receptor protein signaling pathway; cell proliferation; negative regulation of interleukin-23 production; hyperosmotic response; positive regulation of actin filament polymerization; homeostasis of number of cells within a tissue; organization of an anatomical structure; auditory receptor cell morphogenesis; ruffle organization and biogenesis; cerebral cortex radially oriented cell migration; positive regulation of protein amino acid phosphorylation; actin cytoskeleton organization and biogenesis; phagocytosis, engulfment; positive regulation of DNA replication