Anti Beta 1 Adrenergic Receptor Antibodies (b1AR) ELISA Kit for Porcine

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: integral to plasma membrane; early endosome; plasma membrane; nucleus

Molecular Function: protein binding; protein heterodimerization activity; receptor signaling protein activity; dopamine binding; drug binding; norepinephrine binding; epinephrine binding; alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; Ras guanyl-nucleotide exchange factor activity; beta1-adrenergic receptor activity; PDZ domain binding

Biological Process: fear response; diet induced thermogenesis; wound healing; apoptosis; positive regulation of apoptosis; lipid homeostasis; positive regulation of systemic arterial blood pressure; sensory perception of pain; positive regulation of saliva secretion; Rho protein signal transduction; regulation of inhibitory postsynaptic membrane potential; negative regulation of smooth muscle contraction; positive regulation of cAMP biosynthetic process; aging; negative regulation of multicellular organism growth; glycogen catabolic process; adenylate cyclase activation; regulation of calcium ion transport; memory; positive regulation of the force of heart contraction by norepinephrine; protein localization in organelle; heat generation; brown fat cell differentiation; response to cold; positive regulation of heart rate by epinephrine-norepinephrine; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure

Disease: Resting Heart Rate, Variation In