Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) ELISA Kit for Mouse

Name: Mouse EIF2S3 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS755541
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS755541

MBS755541 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) ELISA Kit target analytes in biological samples. The concentration… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3), ELISA Kit

Full Product Name

Mouse Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) ELISA Kit

Product Gene Name

EIF2S3 elisa kit

Species Reactivity

Mouse

Assay Type

Competitive

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Detection Range

100-2500pg/mL

Sensitivity

1.0pg/mL

Preparation and Storage

Store all reagents at 2-8 degree C.

Molecular Weight

51,109 Da

OMIM

300161

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Product Categories/Family for EIF2S3 elisa kit

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of EIF2S3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2S3. It may not necessarily be applicable to this product.

NCBI GI #

4503507

NCBI GeneID

1968

NCBI Accession #

NP_001406.1

UniProt Secondary Accession #

B5BTZ4

UniProt Related Accession #

P41091

GenBank Nucleotide #

NM_001415.3

NCBI Official Full Name

eukaryotic translation initiation factor 2 subunit 3

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa

NCBI Official Symbol

EIF2S3

NCBI Official Synonym Symbols

EIF2; EIF2G; eIF-2gA; EIF2gamma

UniProt Protein Name

Eukaryotic translation initiation factor 2 subunit 3

UniProt Synonym Protein Names

Eukaryotic translation initiation factor 2 subunit gamma X; eIF-2-gamma X; eIF-2gX

Protein Family

Eukaryotic translation initiation factor

UniProt Gene Name

EIF2S3

UniProt Synonym Gene Names

EIF2G; eIF-2-gamma X; eIF-2gX

UniProt Entry Name

IF2G_HUMAN

NCBI Protein Information

eukaryotic translation initiation factor 2 subunit 3; eIF-2gX; eIF-2-gamma X; eukaryotic translation initiation factor 2G; eukaryotic translation initiation factor 2 subunit gamma X

NCBI Summary for EIF2S3

The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]

UniProt Comments for EIF2S3

eIF2-gamma: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: Xp22.2-p22.1

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; translation factor activity, nucleic acid binding; translation initiation factor activity

Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression

Research Articles on EIF2S3

1. The human X-chromosomal neurological disorder characterized by intellectual disability and microcephaly is caused by a missense mutation in eIF2gamma (encoded by EIF2S3), the core subunit of the heterotrimeric eIF2 complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EIF2S3 elisa kit

Products by Pathway	Pathway Diagram
Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies	Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
Cap-dependent Translation Initiation Pathway antibodies	Cap-dependent Translation Initiation Pathway Diagram
Eukaryotic Translation Initiation Pathway antibodies	Eukaryotic Translation Initiation Pathway Diagram
Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway antibodies	Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway Diagram
GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies	GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway antibodies	L13a-mediated Translational Silencing Of Ceruloplasmin Expression Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram

Diseases associated with EIF2S3 elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with EIF2S3 and Nervous System Diseases
Urogenital Abnormalities Antibodies	>1 publications with EIF2S3 and Urogenital Abnormalities
Disorders of Sex Development Antibodies	>1 publications with EIF2S3 and Disorders of Sex Development

Organs/Tissues associated with EIF2S3 elisa kit

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>1 publications with EIF2S3 and Liver
Testis Antibodies	>1 publications with EIF2S3 and Testis
Brain Antibodies	>1 publications with EIF2S3 and Brain