Adipocyte Enhancer-Binding Protein 1 (AEBP1) ELISA Kit for Mouse

This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Transcription factor

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: cytoplasm; extracellular matrix; extracellular space; nucleus

Molecular Function: calmodulin binding; carboxypeptidase activity; metallocarboxypeptidase activity; serine carboxypeptidase activity; transcription corepressor activity; transcription factor activity; zinc ion binding

Biological Process: muscle development; negative regulation of transcription from RNA polymerase II promoter; peptide metabolic process; protein processing; skeletal development; transcription, DNA-dependent