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Cyclin-Dependent Kinase 2 (CDK2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS760622

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human CDK2 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human CDK2 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cyclin-dependent kinase 2 (CDK2), ELISA Kit
Full Product Name
Human Cyclin-dependent kinase 2 ELISA Kit
Product Gene Name
CDK2 elisa kit
Product Synonym Names
CDK2/Cyclin-dependent kinase 2/Cell division protein kinase 2/p33 protein kinase/CDKN2/cdc2-related protein kinase/Cell division kinase 2
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.313-20ng/ml
Sensitivity
0.188ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
– Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of CDK2 elisa kit

Human CDK2 ELISA Kit – Cat# MBS760622

Typical Standard Curve of CDK2 elisa kit

Human CDK2 ELISA Kit, Typical Standard Curve – Cat# MBS760622

Other Notes

Small volumes of CDK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK2 purchase

MBS760622 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cyclin-dependent kinase 2 (CDK2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CDK2. The ELISA analytical biochemical technique of the MBS760622 kit is based on CDK2 antibody-CDK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CDK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CDK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CDK2. It may not necessarily be applicable to this product.

NCBI GI #
41054836
NCBI GeneID
362817
NCBI Accession #
NP_955795.1
UniProt Secondary Accession #
O09136
UniProt Related Accession #
Q63699
GenBank Nucleotide #
NM_199501.1
NCBI Official Full Name
cyclin-dependent kinase 2
NCBI Official Synonym Full Names
cyclin dependent kinase 2
NCBI Official Symbol
Cdk2
UniProt Protein Name
Cyclin-dependent kinase 2
UniProt Synonym Protein Names
Cell division protein kinase 2
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
Cdk2
UniProt Synonym Gene Names
Cdkn2
UniProt Entry Name
CDK2_RAT
NCBI Protein Information
cyclin-dependent kinase 2

UniProt Comments for CDK2

CDK2: a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276

Protein type: EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/CDK1 subfamily; CDK1 subfamily

Cellular Component: Cajal body; chromosome, telomeric region; condensed chromosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; endosome; intracellular membrane-bound organelle; microtubule organizing center; nucleus; transcription factor complex; X chromosome; Y chromosome

Molecular Function: ATP binding; cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; kinase activity; metal ion binding; protein complex binding; protein kinase activity

Biological Process: cell division; cellular response to insulin stimulus; centriole replication; DNA repair; G1/S transition of mitotic cell cycle; histone phosphorylation; lens development in camera-type eye; meiotic cell cycle; mitosis; organ regeneration; peptidyl-serine phosphorylation; positive regulation of cell proliferation; positive regulation of DNA replication initiation; positive regulation of transcription, DNA-dependent; potassium ion transport; protein amino acid phosphorylation; Ras protein signal transduction; regulation of cell cycle; response to cadmium ion; response to cAMP; response to drug; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to toxin
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Research Articles on CDK2

1. that p52SHC3 plays an important role in maintaining the mitotic quiescence of neurons, while p52SHC1 regulates the proliferation of neural stem cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDK2 elisa kit

 Reference Product  PubMed Publications
 Cdkn1a elisa kit  >1263 publications with CDK2 and Cdkn1a
 Cdkn1b elisa kit  >1156 publications with CDK2 and Cdkn1b
 Cdc25a elisa kit  >191 publications with CDK2 and Cdc25a
 Ccna2 elisa kit  >99 publications with CDK2 and Ccna2
 Ccne1 elisa kit  >92 publications with CDK2 and Ccne1
 Cdc6 elisa kit  >74 publications with CDK2 and Cdc6
 Cdkn1c elisa kit  >31 publications with CDK2 and Cdkn1c
 Rb1 elisa kit  >26 publications with CDK2 and Rb1
 Ccne2 elisa kit  >22 publications with CDK2 and Ccne2
 Ccna1 elisa kit  >21 publications with CDK2 and Ccna1

Pathways associated with CDK2 elisa kit

 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 ATM Pathway antibodies  ATM Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CDK-mediated Phosphorylation And Removal Of Cdc6 Pathway antibodies  CDK-mediated Phosphorylation And Removal Of Cdc6 Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Organs/Tissues associated with CDK2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >321 publications with CDK2 and Liver
 Lung Antibodies  >271 publications with CDK2 and Lung
 Prostate Antibodies  >184 publications with CDK2 and Prostate
 Brain Antibodies  >176 publications with CDK2 and Brain
 Colon Antibodies  >167 publications with CDK2 and Colon
 Embryonic Tissue Antibodies  >99 publications with CDK2 and Embryonic Tissue
 Heart Antibodies  >88 publications with CDK2 and Heart
 Thymus Antibodies  >33 publications with CDK2 and Thymus
 Spleen Antibodies  >33 publications with CDK2 and Spleen
 Pancreas Antibodies  >27 publications with CDK2 and Pancreas
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