Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) ELISA Kit for Human

PKR: a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. Controls the activation of several transcription factors such as NF-kappaB, p53 and Stats. Mediates apoptosis induced by many different stimuli, such as LPS, TNF-alpha, viral infection and serum starvation.

Protein type: EC 2.7.11.1; EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, Other; Translation; Other group; PEK family

Cellular Component: cytoplasm; membrane; nucleus; perinuclear region of cytoplasm

Molecular Function: ATP binding; double-stranded RNA binding; eukaryotic translation initiation factor 2alpha kinase activity; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-tyrosine kinase activity; RNA binding; transferase activity

Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; cellular response to amino acid starvation; defense response to virus; immune system process; innate immune response; negative regulation of apoptosis; negative regulation of osteoblast proliferation; negative regulation of translation; negative regulation of viral genome replication; phosphorylation; positive regulation of apoptosis; positive regulation of chemokine production; positive regulation of cytokine production; positive regulation of stress-activated MAPK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to toxin; response to virus; response to vitamin E; transcription, DNA-dependent; translation; unfolded protein response