G-Protein Coupled Estrogen Receptor 1 (GPER) ELISA Kit for Mouse

This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq, Jul 2008]

GPER1: Receptor for estrogen. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7p22.3

Cellular Component: axon; cell junction; cytoplasm; cytoplasmic vesicle membrane; cytosol; dendrite; dendritic shaft; early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; integral to plasma membrane; intracellular; keratin filament; mitochondrial membrane; nerve terminal; nuclear envelope; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; presynaptic active zone; presynaptic membrane; recycling endosome; trans-Golgi network

Molecular Function: chromatin binding; drug binding; estrogen receptor activity; G-protein coupled receptor activity; mineralocorticoid receptor activity; protein binding; steroid binding

Biological Process: apoptotic chromosome condensation; cell cycle; cytosolic calcium ion homeostasis; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; generation of action potential; inflammatory response; innate immune response; mineralocorticoid receptor signaling pathway; negative regulation of cell proliferation; negative regulation of DNA metabolic process; negative regulation of fat cell differentiation; negative regulation of inflammatory response; negative regulation of leukocyte activation; negative regulation of lipid biosynthetic process; negative regulation of protein kinase B signaling cascade; nuclear fragmentation during apoptosis; positive regulation of apoptosis; positive regulation of cAMP biosynthetic process; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; positive regulation of inositol trisphosphate biosynthetic process; positive regulation of insulin secretion; positive regulation of MAPKKK cascade; positive regulation of neurogenesis; positive regulation of neurotransmitter secretion; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; steroid hormone mediated signaling; steroid hormone receptor signaling pathway