P2X Purinoceptor 7 (P2RX7) ELISA Kit for Human

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

P2X7: a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation.

Protein type: Channel, ligand-gated; Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: cell soma; cytoplasm; external side of plasma membrane; integral to nuclear inner membrane; integral to plasma membrane; intercellular junction; membrane; neuromuscular junction; plasma membrane

Molecular Function: ATP binding; ATP-gated cation channel activity; lipopolysaccharide binding; protein binding; protein homodimerization activity; purinergic nucleotide receptor activity; receptor binding

Biological Process: activation of MAPK activity; bleb formation; cell morphogenesis; cell surface receptor linked signal transduction; cellular response to extracellular stimulus; ceramide biosynthetic process; collagen metabolic process; cytolysis; defense response to Gram-positive bacterium; homeostasis of number of cells within a tissue; inflammatory response; innate immune response; membrane budding; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization and biogenesis; multicellular organismal protein catabolic process; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPKKK cascade; phagolysosome formation; phospholipid scrambling; phospholipid transfer to membrane; phospholipid translocation; pore complex biogenesis; positive regulation of bone mineralization; positive regulation of cytolysis; positive regulation of cytoskeleton organization and biogenesis; positive regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; positive regulation of glycolysis; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of mitochondrial depolarization; positive regulation of prostaglandin secretion; positive regulation of T cell mediated cytotoxicity; protein amino acid phosphorylation; protein oligomerization; protein processing; regulation of killing of cells of another organism; regulation of sodium ion transport; release of sequestered calcium ion into cytosol; response to ATP; response to calcium ion; response to drug; response to electrical stimulus; response to lipopolysaccharide; response to mechanical stimulus; response to zinc ion; sensory perception of pain; skeletal morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation

Disease: Leukemia, Chronic Lymphocytic