Nuclear Receptor Coactivator 1 (NCOA1) ELISA Kit for Human

SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described.

Protein type: EC 2.3.1.48; Oncoprotein; Acetyltransferase; Nuclear receptor co-regulator; DNA-binding; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; neuron projection; nuclear chromatin; nucleus

Molecular Function: chromatin binding; DNA binding; enzyme binding; estrogen receptor binding; histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; progesterone receptor binding; protein binding; protein complex binding; protein dimerization activity; protein N-terminus binding; retinoic acid receptor binding; retinoid X receptor binding; transcription coactivator activity; transcription factor binding; transferase activity; transferase activity, transferring acyl groups

Biological Process: cellular response to hormone stimulus; male mating behavior; positive regulation of apoptosis; positive regulation of female receptivity; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to estradiol stimulus; response to progesterone stimulus; response to retinoic acid; transcription, DNA-dependent