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Next to BRCA1 Gene 1 (NBR1) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS761270

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human NBR1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human NBR1 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Next to BRCA1 gene 1 protein (NBR1), ELISA Kit
Full Product Name
Human Next to BRCA1 gene 1 protein ELISA Kit
Product Gene Name
NBR1 elisa kit
Product Synonym Names
NBR1/Protein 1A1-3B/Neighbor of BRCA1 gene 1 protein/Cell migration-inducing gene 19 protein/Membrane component chromosome 17 surface marker 2
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
103,834 Da
OMIM
166945
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of NBR1 elisa kit

Human NBR1 ELISA Kit – Cat# MBS761270

Typical Standard Curve of NBR1 elisa kit

Human NBR1 ELISA Kit, Typical Standard Curve – Cat# MBS761270

Other Notes

Small volumes of NBR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NBR1 purchase

MBS761270 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Next to BRCA1 gene 1 protein (NBR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NBR1. The ELISA analytical biochemical technique of the MBS761270 kit is based on NBR1 antibody-NBR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NBR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NBR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for NBR1. It may not necessarily be applicable to this product.

NCBI GI #
14110381
NCBI GeneID
4077
NCBI Accession #
NP_114068.1
UniProt Secondary Accession #
Q13173; Q15026; Q5J7Q8; Q96GB6; Q9NRF7
UniProt Related Accession #
Q14596
GenBank Nucleotide #
NM_031862.3
NCBI Official Full Name
next to BRCA1 gene 1 protein isoform a
NCBI Official Synonym Full Names
neighbor of BRCA1 gene 1
NCBI Official Symbol
NBR1
NCBI Official Synonym Symbols
IAI3B; M17S2; MIG19; 1A1-3B
UniProt Protein Name
Next to BRCA1 gene 1 protein
UniProt Synonym Protein Names
Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B
Protein Family
Next to BRCA1 gene 1 protein
UniProt Gene Name
NBR1
UniProt Synonym Gene Names
1A13B; KIAA0049; M17S2
UniProt Entry Name
NBR1_HUMAN
NCBI Protein Information
next to BRCA1 gene 1 protein

NCBI Summary for NBR1

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
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UniProt Comments for NBR1

NBR1: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. Homooligomer and heterooligomer. Interacts with TRIM55. Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: autophagic vacuole; cytoplasmic vesicle; cytosol; late endosome; lysosome; M band; membrane; mitochondrion

Molecular Function: mitogen-activated protein kinase binding; protein binding; ubiquitin binding; zinc ion binding

Biological Process: macroautophagy; negative regulation of osteoblast differentiation; protein oligomerization; regulation of bone mineralization; regulation of stress-activated MAPK cascade
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Research Articles on NBR1

1. NBR1 positively correlates with adipose inflammation in human obese patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NBR1 elisa kit

 Reference Product  PubMed Publications
 SQSTM1 elisa kit  >43 publications with NBR1 and SQSTM1
 GABARAP elisa kit  >4 publications with NBR1 and GABARAP
 FEZ1 elisa kit  >2 publications with NBR1 and FEZ1
 GABARAPL2 elisa kit  >2 publications with NBR1 and GABARAPL2
 GABARAPL1 elisa kit  >1 publications with NBR1 and GABARAPL1

Diseases associated with NBR1 elisa kit

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with NBR1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >8 publications with NBR1 and Breast Neoplasms
 Death Antibodies  >8 publications with NBR1 and Death
 Lung Neoplasms Antibodies  >5 publications with NBR1 and Lung Neoplasms
 Lung Diseases Antibodies  >5 publications with NBR1 and Lung Diseases
 Cardiovascular Diseases Antibodies  >4 publications with NBR1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >4 publications with NBR1 and Liver Diseases
 Inflammation Antibodies  >4 publications with NBR1 and Inflammation
 Neoplasm Metastasis Antibodies  >2 publications with NBR1 and Neoplasm Metastasis
 Pain Antibodies  >2 publications with NBR1 and Pain

Organs/Tissues associated with NBR1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with NBR1 and Blood
 Heart Antibodies  >13 publications with NBR1 and Heart
 Muscle Antibodies  >12 publications with NBR1 and Muscle
 Brain Antibodies  >11 publications with NBR1 and Brain
 Lung Antibodies  >10 publications with NBR1 and Lung
 Ovary Antibodies  >6 publications with NBR1 and Ovary
 Liver Antibodies  >5 publications with NBR1 and Liver
 Bone Antibodies  >5 publications with NBR1 and Bone
 Lymph Node Antibodies  >3 publications with NBR1 and Lymph Node
 Kidney Antibodies  >3 publications with NBR1 and Kidney
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