DNA Topoisomerase 2-Alpha (TOP2A) ELISA Kit for Human

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]

TOP2A: a DNA topoisomerase. Controls of topological states of DNA by transient breakage and rejoining of DNA. Makes double-strand breaks. Four splice variant isoforms have been described.

Protein type: EC 5.99.1.3; Isomerase

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: centriole; DNA topoisomerase complex (ATP-hydrolyzing); nuclear chromosome; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: chromatin binding; DNA bending activity; DNA binding; DNA topoisomerase (ATP-hydrolyzing) activity; DNA-dependent ATPase activity; drug binding; enzyme binding; histone deacetylase binding; magnesium ion binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding; ubiquitin binding

Biological Process: apoptotic chromosome condensation; chromosome segregation; DNA ligation; DNA topological change; DNA unwinding during replication; mitotic recombination; positive regulation of apoptosis; positive regulation of retroviral genome replication; positive regulation of viral genome replication; protein sumoylation; regulation of circadian rhythm; resolution of meiotic joint molecules as recombinants; response to DNA damage stimulus; sister chromatid segregation