Nuclear Factor of Activated T-Cells, Cytoplasmic 1 (NFATC1) ELISA Kit for Human

NFAT2: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure.

Protein type: Transcription factor; DNA-binding

Cellular Component: cytoplasm; nuclear chromatin; nucleus; transcription factor complex

Molecular Function: chromatin binding; DNA binding; mitogen-activated protein kinase p38 binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: B-1a B cell differentiation; calcineurin-NFAT signaling pathway; calcium ion transport; epithelial to mesenchymal transition; G1/S transition of mitotic cell cycle; heart development; lymphangiogenesis; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of hair cycle; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transition between fast and slow fiber