Fibroblast Growth Factor 20 (FGF20) ELISA Kit for Human

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region; intracellular

Molecular Function: fibroblast growth factor receptor binding; growth factor activity

Biological Process: activation of MAPKK activity; axon guidance; cell-cell signaling; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; inner ear receptor cell differentiation; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of cell proliferation; Ras protein signal transduction; regulation of cardiac muscle cell proliferation; signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway

Disease: Renal Hypodysplasia/aplasia 2