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Prostaglandin E Synthase (PTGES) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS761843

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human PTGES antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human PTGES antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Prostaglandin E synthase (PTGES), ELISA Kit
Full Product Name
Human Prostaglandin E synthase ELISA Kit
Product Gene Name
PTGES elisa kit
Product Synonym Names
PTGES/Prostaglandin E synthase/p53-induced gene 12 protein/Microsomal glutathione S-transferase 1-like 1/MGST1-L1/Microsomal prostaglandin E synthase 1/MPGES-1/MGST1L1/MPGES1/PGES/PIG12/MGST-IV/MGST1-L1/MPGES/PP102/PP1294/TP53I12/mPGES-1
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
1.563-100ng/ml
Sensitivity
0.938ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
17,102 Da
OMIM
605172
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of PTGES elisa kit

Human PTGES ELISA Kit – Cat# MBS761843

Typical Standard Curve of PTGES elisa kit

Human PTGES ELISA Kit, Typical Standard Curve – Cat# MBS761843

Other Notes

Small volumes of PTGES elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGES purchase

MBS761843 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Prostaglandin E synthase (PTGES) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PTGES. The ELISA analytical biochemical technique of the MBS761843 kit is based on PTGES antibody-PTGES antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTGES antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTGES. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PTGES. It may not necessarily be applicable to this product.

NCBI GI #
4758910
NCBI GeneID
9536
NCBI Accession #
NP_004869.1
UniProt Secondary Accession #
O14900; Q5SZC0
UniProt Related Accession #
O14684
GenBank Nucleotide #
NM_004878.4
NCBI Official Full Name
prostaglandin E synthase
NCBI Official Synonym Full Names
prostaglandin E synthase
NCBI Official Symbol
PTGES
NCBI Official Synonym Symbols
PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
UniProt Protein Name
Prostaglandin E synthase
UniProt Synonym Protein Names
Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
Protein Family
Prostaglandin E synthase
UniProt Gene Name
PTGES
UniProt Synonym Gene Names
MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1
UniProt Entry Name
PTGES_HUMAN
NCBI Protein Information
prostaglandin E synthase

NCBI Summary for PTGES

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
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UniProt Comments for PTGES

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.

Protein type: Lipid Metabolism - arachidonic acid; Isomerase; Nuclear envelope; EC 5.3.99.3; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm

Molecular Function: glutathione binding; prostaglandin-E synthase activity

Biological Process: acute inflammatory response; arachidonic acid metabolic process; chronic inflammatory response; cyclooxygenase pathway; negative regulation of cell proliferation; prostaglandin biosynthetic process; prostaglandin metabolic process; response to calcium ion; response to cytokine stimulus; response to lipopolysaccharide; response to organic cyclic substance; response to retinoic acid; signal transduction
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Research Articles on PTGES

1. we investigated the changes in promoter methylation patterns using methylation arrays and observed that the promoters of immunomodulatory factors, COX2 and PTGES, and migration-related factors, CXCR2 and CXCR4, were hypomethylated after 5-aza treatment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PTGES elisa kit

 Reference Product  PubMed Publications
 PTGS2 elisa kit  >56 publications with PTGES and PTGS2
 PTGS1 elisa kit  >14 publications with PTGES and PTGS1
 PTGIS elisa kit  >8 publications with PTGES and PTGIS
 PTGES2 elisa kit  >7 publications with PTGES and PTGES2
 PTGES3 elisa kit  >7 publications with PTGES and PTGES3
 PTGDS elisa kit  >6 publications with PTGES and PTGDS
 TBXAS1 elisa kit  >3 publications with PTGES and TBXAS1
 HPGDS elisa kit  >2 publications with PTGES and HPGDS

Pathways associated with PTGES elisa kit

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway antibodies  Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway Diagram

Diseases associated with PTGES elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >40 publications with PTGES and Inflammation
 Necrosis Antibodies  >12 publications with PTGES and Necrosis
 Disease Models, Animal Antibodies  >9 publications with PTGES and Disease Models, Animal
 Nervous System Diseases Antibodies  >8 publications with PTGES and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >6 publications with PTGES and Cardiovascular Diseases
 Pain Antibodies  >5 publications with PTGES and Pain
 Adenocarcinoma Antibodies  >4 publications with PTGES and Adenocarcinoma
 Hypertension Antibodies  >4 publications with PTGES and Hypertension
 Breast Neoplasms Antibodies  >3 publications with PTGES and Breast Neoplasms
 Weight Loss Antibodies  >3 publications with PTGES and Weight Loss

Organs/Tissues associated with PTGES elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with PTGES and Brain
 Uterus Antibodies  >14 publications with PTGES and Uterus
 Bone Antibodies  >10 publications with PTGES and Bone
 Kidney Antibodies  >5 publications with PTGES and Kidney
 Liver Antibodies  >5 publications with PTGES and Liver
 Connective Tissue Antibodies  >5 publications with PTGES and Connective Tissue
 Lung Antibodies  >5 publications with PTGES and Lung
 Placenta Antibodies  >5 publications with PTGES and Placenta
 Ovary Antibodies  >4 publications with PTGES and Ovary
 Intestine Antibodies  >2 publications with PTGES and Intestine
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