Endothelin-1 (EDN1) ELISA Kit for Human

This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

EDN1: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24.1

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space

Molecular Function: cytokine activity; endothelin A receptor binding; endothelin B receptor binding; hormone activity; protein binding

Biological Process: artery smooth muscle contraction; body fluid secretion; calcium-mediated signaling; cartilage development; cell growth; cell surface receptor linked signal transduction; cell-cell signaling; dorsal/ventral pattern formation; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); epithelial fluid transport; G-protein coupled receptor protein signaling pathway; G-protein signaling, phospholipase D activating pathway; glucose transport; heart development; histamine secretion; in utero embryonic development; inositol phosphate-mediated signaling; leukocyte activation; maternal process involved in parturition; membrane depolarization; middle ear morphogenesis; multicellular organismal aging; negative regulation of blood coagulation; negative regulation of cAMP biosynthetic process; negative regulation of cellular protein metabolic process; negative regulation of hormone secretion; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; neutrophil chemotaxis; nitric oxide transport; patterning of blood vessels; peptide hormone secretion; phosphoinositide 3-kinase cascade; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell size; positive regulation of heart rate; positive regulation of hormone secretion; positive regulation of JNK activity; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of nitric oxide biosynthetic process; positive regulation of odontogenesis; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of transcription from RNA polymerase II promoter; prostaglandin biosynthetic process; protein kinase C activation; protein kinase C deactivation; regulation of pH; regulation of sensory perception of pain; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction; respiratory gaseous exchange; response to activity; response to amino acid stimulus; response to lipopolysaccharide; response to nicotine; response to ozone; response to testosterone stimulus; rhythmic excitation; sensory perception of pain; superoxide release; vasoconstriction; vein smooth muscle contraction

Disease: Auriculocondylar Syndrome 3; Question Mark Ears, Isolated