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Disabled Homolog 2 (DAB2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762012

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human DAB2 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human DAB2 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Disabled homolog 2 (DAB2), ELISA Kit
Full Product Name
Human Disabled homolog 2 ELISA Kit
Product Gene Name
DAB2 elisa kit
Product Synonym Names
Disabled-2/DOC2/Differentially-expressed protein 2/disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)/disabled homolog 2; mitogen-responsive phosphoprotein (Drosophila)/DOC-2DOC2disabled homolog 2/FLJ26626/mitogen-responsive phosphoprotein
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
58,822 Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of DAB2 elisa kit

Human DAB2 ELISA Kit – Cat# MBS762012

Typical Standard Curve of DAB2 elisa kit

Human DAB2 ELISA Kit, Typical Standard Curve – Cat# MBS762012

Other Notes

Small volumes of DAB2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DAB2 purchase

MBS762012 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Disabled homolog 2 (DAB2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DAB2. The ELISA analytical biochemical technique of the MBS762012 kit is based on DAB2 antibody-DAB2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DAB2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DAB2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for DAB2. It may not necessarily be applicable to this product.

NCBI GI #
83776557
NCBI GeneID
13132
NCBI Accession #
NP_075607.2
UniProt Secondary Accession #
Q3U3K1; Q91W56; Q923E1
UniProt Related Accession #
P98078
GenBank Nucleotide #
NM_023118.5
NCBI Official Full Name
disabled homolog 2 isoform a
NCBI Official Synonym Full Names
disabled 2, mitogen-responsive phosphoprotein
NCBI Official Symbol
Dab2
NCBI Official Synonym Symbols
p96; Doc2; Doc-2; AA960054; AI957090; D15Wsu122e; 5730435J12Rik; D630005B22Rik
UniProt Protein Name
Disabled homolog 2
UniProt Synonym Protein Names
Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; DOC-2; Mitogen-responsive phosphoprotein
Protein Family
Disabled
UniProt Gene Name
Dab2
UniProt Synonym Gene Names
Doc2; DOC-2
UniProt Entry Name
DAB2_MOUSE
NCBI Protein Information
disabled homolog 2

UniProt Comments for DAB2

DAB2: an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described.

Protein type: Adaptor/scaffold; Tumor suppressor

Cellular Component: apical plasma membrane; clathrin coat of coated pit; clathrin coated vesicle membrane; clathrin-coated vesicle; coated pit; cytoplasm; cytoplasmic vesicle; focal adhesion; intracellular membrane-bound organelle; membrane; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: clathrin binding; integrin binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide binding; protein binding; protein C-terminus binding; SMAD binding

Biological Process: activation of JNK activity; apoptosis; cell differentiation; cellular morphogenesis during differentiation; clathrin cage assembly; endocytosis; endoderm development; excretion; in utero embryonic development; leading edge cell differentiation; multicellular organismal development; negative regulation of apoptosis; negative regulation of cell growth; negative regulation of epithelial cell proliferation; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; pinocytosis; positive regulation of aldosterone biosynthetic process; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of endocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; positive regulation of receptor internalization; positive regulation of receptor recycling; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; protein transport; receptor-mediated endocytosis; response to steroid hormone stimulus; transport; Wnt receptor signaling pathway
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Research Articles on DAB2

1. Dab2 expression is induced by hormones

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DAB2 elisa kit

 Reference Product  PubMed Publications
 Grb2 elisa kit  >7 publications with DAB2 and Grb2
 Eps15 elisa kit  >4 publications with DAB2 and Eps15
 Myo6 elisa kit  >2 publications with DAB2 and Myo6

Pathways associated with DAB2 elisa kit

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Formation Of Annular Gap Junctions Pathway antibodies  Formation Of Annular Gap Junctions Pathway Diagram
 Gap Junction Degradation Pathway antibodies  Gap Junction Degradation Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram

Diseases associated with DAB2 elisa kit

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >56 publications with DAB2 and Carcinoma
 Adenocarcinoma Antibodies  >17 publications with DAB2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >17 publications with DAB2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >16 publications with DAB2 and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >12 publications with DAB2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >12 publications with DAB2 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >11 publications with DAB2 and Kidney Diseases
 Lung Neoplasms Antibodies  >10 publications with DAB2 and Lung Neoplasms
 Lung Diseases Antibodies  >10 publications with DAB2 and Lung Diseases
 Fibrosis Antibodies  >8 publications with DAB2 and Fibrosis

Organs/Tissues associated with DAB2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >51 publications with DAB2 and Other
 Kidney Antibodies  >33 publications with DAB2 and Kidney
 Blood Antibodies  >26 publications with DAB2 and Blood
 Brain Antibodies  >19 publications with DAB2 and Brain
 Embryonic Tissue Antibodies  >18 publications with DAB2 and Embryonic Tissue
 Lung Antibodies  >15 publications with DAB2 and Lung
 Liver Antibodies  >11 publications with DAB2 and Liver
 Muscle Antibodies  >10 publications with DAB2 and Muscle
 Bone Antibodies  >8 publications with DAB2 and Bone
 Intestine Antibodies  >8 publications with DAB2 and Intestine
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