Disabled Homolog 1 (DAB1) ELISA Kit for Human

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: apical part of cell; brush border; cell soma; cytosol; intracellular membrane-bound organelle; membrane; microtubule organizing center; neuron projection; nucleolus; perinuclear region of cytoplasm; postsynaptic density

Molecular Function: phosphoinositide 3-kinase binding; protein binding

Biological Process: adult walking behavior; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; cerebellum structural organization; dendrite development; Golgi localization; midgut development; negative regulation of astrocyte differentiation; negative regulation of axonogenesis; negative regulation of cell adhesion; negative regulation of JAK-STAT cascade; positive regulation of neuron differentiation; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; response to drug; small GTPase mediated signal transduction; ventral spinal cord development