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Interferon-Inducible Protein AIM2 (AIM2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762160

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human AIM2 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human AIM2 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interferon-inducible protein AIM2, ELISA Kit
Full Product Name
Human Interferon-inducible protein AIM2 ELISA Kit
Product Gene Name
AIM2 elisa kit
Product Synonym Names
AIM2/Interferon-inducible protein AIM2
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
38,954 Da
OMIM
604578
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of AIM2 elisa kit

Human AIM2 ELISA Kit – Cat# MBS762160

Typical Standard Curve of AIM2 elisa kit

Human AIM2 ELISA Kit, Typical Standard Curve – Cat# MBS762160

Other Notes

Small volumes of AIM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIM2 purchase

MBS762160 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interferon-inducible protein AIM2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing AIM2. The ELISA analytical biochemical technique of the MBS762160 kit is based on AIM2 antibody-AIM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect AIM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, AIM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.

NCBI GI #
4757734
NCBI GeneID
9447
NCBI Accession #
NP_004824.1
UniProt Secondary Accession #
Q5T3V9; Q96FG9; A8K7M7
UniProt Related Accession #
O14862
GenBank Nucleotide #
NM_004833.1
NCBI Official Full Name
interferon-inducible protein AIM2
NCBI Official Synonym Full Names
absent in melanoma 2
NCBI Official Symbol
AIM2
NCBI Official Synonym Symbols
PYHIN4
UniProt Protein Name
Interferon-inducible protein AIM2
UniProt Synonym Protein Names
Absent in melanoma 2
Protein Family
Interferon-inducible protein
UniProt Gene Name
AIM2
UniProt Entry Name
AIM2_HUMAN
NCBI Protein Information
interferon-inducible protein AIM2

NCBI Summary for AIM2

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

UniProt Comments for AIM2

AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: double-stranded DNA binding; identical protein binding; protein binding

Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; apoptosis; immune response; inflammatory response; inhibition of NF-kappaB transcription factor; innate immune response; interleukin-1 beta secretion; positive regulation of defense response to virus by host; positive regulation of interleukin-1 beta production; positive regulation of interleukin-1 beta secretion; positive regulation of protein oligomerization; tumor necrosis factor-mediated signaling pathway
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Research Articles on AIM2

1. These results suggest that AIM2 expressed in human dental pulp plays an important role in the immune defense by activating the inflammasome signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AIM2 elisa kit

 Reference Product  PubMed Publications
 CASP1 elisa kit  >180 publications with AIM2 and CASP1
 NLRP3 elisa kit  >148 publications with AIM2 and NLRP3
 NLRC4 elisa kit  >73 publications with AIM2 and NLRC4
 NLRP1 elisa kit  >42 publications with AIM2 and NLRP1
 PYCARD elisa kit  >30 publications with AIM2 and PYCARD
 DDX58 elisa kit  >5 publications with AIM2 and DDX58
 EIF2AK2 elisa kit  >1 publications with AIM2 and EIF2AK2

Pathways associated with AIM2 elisa kit

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The AIM2 Inflammasome Pathway antibodies  The AIM2 Inflammasome Pathway Diagram

Diseases associated with AIM2 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >131 publications with AIM2 and Inflammation
 Disease Models, Animal Antibodies  >19 publications with AIM2 and Disease Models, Animal
 Necrosis Antibodies  >19 publications with AIM2 and Necrosis
 Nervous System Diseases Antibodies  >13 publications with AIM2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >11 publications with AIM2 and Cardiovascular Diseases
 Lung Diseases Antibodies  >8 publications with AIM2 and Lung Diseases
 Pneumonia Antibodies  >6 publications with AIM2 and Pneumonia
 Fibrosis Antibodies  >5 publications with AIM2 and Fibrosis
 Breast Neoplasms Antibodies  >4 publications with AIM2 and Breast Neoplasms
 Fatty Liver Antibodies  >4 publications with AIM2 and Fatty Liver

Organs/Tissues associated with AIM2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with AIM2 and Blood
 Bone Antibodies  >26 publications with AIM2 and Bone
 Lung Antibodies  >19 publications with AIM2 and Lung
 Brain Antibodies  >18 publications with AIM2 and Brain
 Intestine Antibodies  >10 publications with AIM2 and Intestine
 Mouth Antibodies  >8 publications with AIM2 and Mouth
 Lymph Node Antibodies  >4 publications with AIM2 and Lymph Node
 Spleen Antibodies  >4 publications with AIM2 and Spleen
 Connective Tissue Antibodies  >2 publications with AIM2 and Connective Tissue
 Cervix Antibodies  >1 publications with AIM2 and Cervix
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